3-{4-[(benzyloxycarbonylamino)methyl]piperidine-4-carboxamido}phenyl N,N-dimethylcarbamate

Base Information

Chemical Name:3-{4-[(benzyloxycarbonylamino)methyl]piperidine-4-carboxamido}phenyl N,N-dimethylcarbamate
CAS No.:1192189-68-6
Molecular Formula:C₂₄H₃₀N₄O₅*ClH
Molecular Weight:490.987
Hs Code.:

Synonyms:3-{4-[(benzyloxycarbonylamino)methyl]piperidine-4-carboxamido}phenyl N,N-dimethylcarbamate

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Chemical Property of 3-{4-[(benzyloxycarbonylamino)methyl]piperidine-4-carboxamido}phenyl N,N-dimethylcarbamate

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Technology Process of 3-{4-[(benzyloxycarbonylamino)methyl]piperidine-4-carboxamido}phenyl N,N-dimethylcarbamate

There total 6 articles about 3-{4-[(benzyloxycarbonylamino)methyl]piperidine-4-carboxamido}phenyl N,N-dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192189-67-5
tert-butyl 4-[(benzyloxycarbonylamino)methyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

: 1192189-68-6
3-{4-[(benzyloxycarbonylamino)methyl]piperidine-4-carboxamido}phenyl N,N-dimethylcarbamate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 50 ℃; for 1h;

Reference yield:

: 362703-35-3
1-tert-butyl 4-methyl 4-(aminomethyl)piperidine-1,4-dicarboxylate

: 1192189-68-6
3-{4-[(benzyloxycarbonylamino)methyl]piperidine-4-carboxamido}phenyl N,N-dimethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 50 °C / Inert atmosphere

2.2: pH 5 / Inert atmosphere

3.1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

3.2: Inert atmosphere; Cooling with ice

4.1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; methanol; oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/ml500367g

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1192189-68-6
3-{4-[(benzyloxycarbonylamino)methyl]piperidine-4-carboxamido}phenyl N,N-dimethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 50 °C / Inert atmosphere

2.2: pH 5 / Inert atmosphere

3.1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

3.2: Inert atmosphere; Cooling with ice

4.1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; methanol; oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/ml500367g