Chemical Property of Corticosterone
Chemical Property:
- Appearance/Colour:white to light yellow powder
- Vapor Pressure:2.07E-13mmHg at 25°C
- Melting Point:179-183 °C (lit.)
- Refractive Index:1.575
- Boiling Point:529.2 °C at 760 mmHg
- Flash Point:288 °C
- PSA：74.60000
- Density:1.21 g/cm3
- LogP:2.66670
- Storage Temp.:Store at RT
- Solubility.:Chloroform (Sparingly, Sonicated), Ethanol (Slightly, Sonicated), Methanol (Slig
- Water Solubility.:240.5mg/L(37 oC)
- XLogP3:1.9
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:346.21440943
- Heavy Atom Count:25
- Complexity:638
- Purity/Quality:
-
98% HPLC *data from raw suppliers
Corticosterone *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi,
N,
Xn,
T
- Hazard Codes:Xi,N,Xn,T,F
- Statements:
43-40-39/23/24/25-23/24/25-11
- Safety Statements:
36-22-45-36/37-16
- MSDS Files:
-
Useful:
- Canonical SMILES:CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
- Isomeric SMILES:C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O
- Recent ClinicalTrials:Comparison of Hyaluronic Acid and Corticosteroid Intra-articular Injections for the Treatment of Osteoarthritis of the Hip
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Description
Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors. It is produced in response to ACTH (corticotropic hormone) and is the precursor to aldosterone synthesis. Since the production of glucocorticoids is increased by stress, it is often used as a biomarker of stress. Plasma corticosterone levels have a circadian variation and corticosterone may be important in the regulation of the sleep-wake cycle.
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Uses
Glucocorticoid; an intermediate in the biosynthesis of aldosterone, isolated from the adrenal cortex. Corticosterone: HBC complex has been used: in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity to induce acute stress in mice in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription Corticosteroid is an activator of MCR.
