4-(2-(4-(2-chloropyridin-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile

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Chemical Name:4-(2-(4-(2-chloropyridin-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile
CAS No.:1426389-03-8
Molecular Formula:C₂₀H₁₄ClN₅OS
Molecular Weight:407.883
Hs Code.:

Synonyms:4-(2-(4-(2-chloropyridin-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile

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Chemical Property of 4-(2-(4-(2-chloropyridin-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile

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Technology Process of 4-(2-(4-(2-chloropyridin-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile

There total 2 articles about 4-(2-(4-(2-chloropyridin-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1426389-03-8
4-(2-(4-(2-chloropyridin-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile

Guidance literature:: In N,N-dimethyl-formamide; at 150 ℃; for 0.0833333h; Sealed tube;

at 200 ℃; for 0.166667h;

Reference yield: 38.0%

: 20099-89-2
4-Cyanophenacyl bromide

: 1366060-25-4
C₉H₁₇NO₂S

: 57-13-6
urea

: 101066-61-9
2-chloropyridine-4-carbaldehyde

: 1426389-03-8
4-(2-(4-(2-chloropyridin-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)thiazol-4-yl)benzonitrile

Guidance literature:: 4-Cyanophenacyl bromide; C₉H₁₇NO₂S; In N,N-dimethyl-formamide; at 150 ℃; for 0.0833333h; under 4500.45 Torr; Inert atmosphere; Sealed tube;

urea; 2-chloropyridine-4-carbaldehyde; In N,N-dimethyl-formamide; at 200 ℃; for 0.166667h; under 4500.45 Torr; Inert atmosphere; Sealed tube;
DOI:10.1016/j.bmc.2017.03.061