2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester

Base Information

Chemical Name:2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester
CAS No.:790230-09-0
Molecular Formula:C₂₇H₂₇NO₄
Molecular Weight:429.516
Hs Code.:

Synonyms:2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester

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Chemical Property of 2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester

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Technology Process of 2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester

There total 10 articles about 2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 790230-08-9
benzyl 2-bromo-5-methylbenzoate

: 790230-07-8
{2-formyl-4-[(isobutylamino)carbonyl]penyl}boronic acid

: 790230-09-0
2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 120 ℃; for 24h;
DOI:10.1016/j.bmc.2006.08.010

Reference yield:

: 790230-04-5
4-bromo-3-(hydroxymethyl)benzoic acid

: 790230-09-0
2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4.27 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 20 °C

2.1: MnO₂ / CHCl₃ / 1 h / 70 °C

3.1: 3.53 g / 4-methylbenzenesulfonic acid monohydrate / toluene / 12 h / Heating

4.1: n-butyl lithium / tetrahydrofuran; hexane / 2 h / -78 °C

4.2: triisopropyl borate / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

4.3: 280 mg / hydrochloric acid / tetrahydrofuran; hexane; H₂O / 3 h / 20 °C

5.1: K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 24 h / 120 °C

With manganese(IV) oxide; potassium phosphate; n-butyllithium; p-toluenesulfonic acid monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; chloroform; N,N-dimethyl-formamide; toluene; 5.1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.08.010

Reference yield:

: 4-bromo-3-formyl-N-isobutyl-benzamide

: 790230-09-0
2'-formyl-4'-isobutylcarbamoyl-4-methyl-biphenyl-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3.53 g / 4-methylbenzenesulfonic acid monohydrate / toluene / 12 h / Heating

2.1: n-butyl lithium / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: triisopropyl borate / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

2.3: 280 mg / hydrochloric acid / tetrahydrofuran; hexane; H₂O / 3 h / 20 °C

3.1: K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 24 h / 120 °C

With potassium phosphate; n-butyllithium; p-toluenesulfonic acid monohydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene; 3.1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.08.010