(2R)-N-[(2S)-2-methoxy-3-phenylpropanoyl]bornane-10,2-sultam

Base Information

• Chemical Name: (2R)-N-[(2S)-2-methoxy-3-phenylpropanoyl]bornane-10,2-sultam
• CAS No.: 127392-97-6
• Molecular Formula: C₂₀H₂₇NO₄S
• Molecular Weight: 377.505
• Mol file: 127392-97-6.mol

Synonyms:(2R)-N-[(2S)-2-methoxy-3-phenylpropanoyl]bornane-10,2-sultam

Chemical Property of (2R)-N-[(2S)-2-methoxy-3-phenylpropanoyl]bornane-10,2-sultam

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-N-[(2S)-2-methoxy-3-phenylpropanoyl]bornane-10,2-sultam

There total 2 articles about (2R)-N-[(2S)-2-methoxy-3-phenylpropanoyl]bornane-10,2-sultam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

benzyl bromide (100-39-0) + (2R)-N-(2-methoxyethanoyl)bornane-10,2-sultam (127392-85-2) → (2R)-N-[(2S)-2-methoxy-3-phenylpropanoyl]bornane-10,2-sultam (127392-97-6)

Guidance literature:

(2R)-N-(2-methoxyethanoyl)bornane-10,2-sultam; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

benzyl bromide; In tetrahydrofuran; Further stages.;

DOI:10.1039/b200976e

Reference yield:

(2R)-N-(2-methoxyethanoyl)bornane-10,2-sultam (127392-85-2) + iodomethylbenzene (620-05-3) → (2R)-N-[(2S)-2-methoxy-3-phenylpropanoyl]bornane-10,2-sultam (127392-97-6)

Guidance literature:

With sodium hexamethyldisilazane; Yield given. Multistep reaction; 1.) THF, -78 deg C, 1 h; 2.) HMPA, slowly to room temp.;

DOI:10.1016/S0040-4039(01)93810-9

Reference yield: 73.0%

vinylmagnesium chloride (3536-96-7) + (2R)-N-[(2S)-2-methoxy-3-phenylpropanoyl]bornane-10,2-sultam (127392-97-6) → (4S)-4-methoxy-5-phenyl-3-vinylpent-1-en-3-ol

Guidance literature:

vinylmagnesium chloride; With cerium(III) chloride; In tetrahydrofuran;

(2R)-N-[(2S)-2-methoxy-3-phenylpropanoyl]bornane-10,2-sultam; In tetrahydrofuran; at -78 ℃; Further stages.;

DOI:10.1039/b200976e

upstream raw materials:

(2R)-N-(2-methoxyethanoyl)bornane-10,2-sultam

iodomethylbenzene

benzyl bromide