Technology Process of methyl 2-methoxy-3,5-dimethylbenzoate
There total 3 articles about methyl 2-methoxy-3,5-dimethylbenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyl 3-iodo-2-methoxy-5-methylbenzoate;
With
tetrabutylammomium bromide; potassium carbonate; palladium dichloride;
In
N,N-dimethyl acetamide;
Schlenk technique;
Inert atmosphere;
carbonic acid dimethyl ester;
In
N,N-dimethyl acetamide;
at 105 ℃;
for 12h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/jacs.0c13057
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium iodide; sodium hydroxide; sodium hypochlorite / methanol; water / 2 h / 0 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
3.1: palladium dichloride; tetrabutylammomium bromide; potassium carbonate / N,N-dimethyl acetamide / Schlenk technique; Inert atmosphere
3.2: 12 h / 105 °C / Schlenk technique; Inert atmosphere
With
sodium hypochlorite; tetrabutylammomium bromide; potassium carbonate; sodium iodide; sodium hydroxide; palladium dichloride;
In
methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1021/jacs.0c13057
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
2.1: palladium dichloride; tetrabutylammomium bromide; potassium carbonate / N,N-dimethyl acetamide / Schlenk technique; Inert atmosphere
2.2: 12 h / 105 °C / Schlenk technique; Inert atmosphere
With
tetrabutylammomium bromide; potassium carbonate; palladium dichloride;
In
N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jacs.0c13057
