S-(4-Methylphenyl)-thiocinnamat

Base Information

• Chemical Name: S-(4-Methylphenyl)-thiocinnamat
• CAS No.: 57830-63-4
• Molecular Formula: C₁₆H₁₄OS
• Molecular Weight: 254.353
• Mol file: 57830-63-4.mol

Synonyms:S-(4-Methylphenyl)-thiocinnamat

Chemical Property of S-(4-Methylphenyl)-thiocinnamat

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-(4-Methylphenyl)-thiocinnamat

There total 14 articles about S-(4-Methylphenyl)-thiocinnamat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

di(p-tolyl) disulfide (103-19-5) + (E)-1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-phenylprop-2-en-1-one (328012-09-5) → (E)-3-phenylthioacrylic acid S-p-tolyl ester (57830-63-4)

Guidance literature:

di(p-tolyl) disulfide; With samarium diiodide; In tetrahydrofuran; at 20 ℃;

(E)-1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-phenylprop-2-en-1-one; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield: 89.0%

cinnamoyl chloride (102-92-1,17082-09-6) + para-thiocresol (106-45-6) → S-(4-Methylphenyl)-thiocinnamat (57830-63-4)

Guidance literature:

With zinc(II) oxide; at 20 ℃; for 0.5h;

DOI:10.1071/CH08202

Reference yield: 85.0%

2-phenylvinyl iodide (101349-79-5) + 2-(p-tolylthio)-2-oxoacetic acid (106871-53-8) → (E)-3-phenylthioacrylic acid S-p-tolyl ester (57830-63-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl acetamide; at 25 ℃; for 8h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.9b03701

upstream raw materials:

cinnamoyl chloride

para-thiocresol

Cinnamic acid

Cinnamoyl chloride

Downstream raw materials:

3-phenylpropanoyl-CoA

cinnamoyl-CoA

(E)-diphenyl(styryl)phosphine oxide

[Pt(P(C₆H₅)3)2(CH₃C₆H₄SC(O)CHCHC₆H₅)]