Synonyms:bicyclohexanone
98% *data from raw suppliers
2-Cyclohexylcyclohexanone >97.0%(GC) *data from reagent suppliers
There total 75 articles about 2-Cyclohexylcyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 64.0%
Reference yield: 32.9%
Reference yield: 4.1%
The study presents a novel photo-induced inverse electron-demand Diels–Alder cycloaddition (photo-iEDDAC) reaction for the rapid and spatiotemporal control of tetrazine-bearing protein labeling in living cells. Researchers designed a cyclopropenone-caged dibenzoannulated bicyclo[6.1.0]nonyne probe (photo-DMBO) that is inert towards tetrazines until it undergoes light-activation at 365 nm, after which it rapidly reacts with tetrazine-modified proteins via iEDDAC. The study utilized various chemicals, including tetrazine-containing amino acids (TetK and mTetK) for genetic encoding and site-specific incorporation into proteins, and a PylRS mutant for efficient incorporation. The photo-DMBO compound and its derivatives were synthesized for light-triggered reactivity towards tetrazine proteins. The purpose of these chemicals was to enable selective and rapid protein labeling in vitro and in cellulo, with potential applications in biology, medicine, and materials science.
The study focuses on the identification and application of isomeric cyclopropenes in bioorthogonal chemistry, which allows for the selective labeling and tracking of biomolecules within complex biological systems without interfering with native biochemical processes. The researchers utilized two types of cyclopropenes: 1,3-disubstituted cyclopropenes, which react with tetrazines through an inverse electron-demand Diels?Alder (IED-DA) reaction, and 3,3-disubstituted cyclopropenes, which undergo 1,3-dipolar cycloaddition with nitrile imines. These reactions were selected for their orthogonality, meaning they can occur simultaneously without interfering with each other, which is crucial for studying multiple biomolecules at once. The purpose of using these specific chemicals was to develop a method for concurrent tagging of biomolecules in complex environments, such as cells and organisms, to monitor multicomponent processes. The study also involved computational analyses using density functional theory (DFT) to predict the reactivity of these cyclopropenes and experimental synthesis and testing of the cyclopropenes with model tetrazines and nitrile imines to validate the theoretical predictions.
The study describes the modular synthesis of nonpeptidic α-helix mimetics based on an oxazole–pyrrole–piperazine scaffold. This scaffold is designed to present a hydrophobic surface for recognition and a hydrophilic edge rich in hydrogen-bond donors and acceptors. The synthesis involves several key chemicals and steps: Tetrazine 5 is used in inverse-electron-demand Diels–Alder reactions with various dienophiles (such as alkynes 6a, 6b, and enol ether 7) to form pyridazine diesters 3a–3d. These pyridazines are then reduced to pyrroles, and the piperazine moiety is introduced through peptide coupling with piperazines 4a and 4b. The oxazole moiety is introduced by coupling amino alcohols (2a–c) onto the remaining ester, followed by oxidation and oxazole formation. The final reduction of the pyridazine ring to pyrrole and removal of the Boc protecting group yield the desired α-helix mimetics. The study demonstrates the synthesis of a small library of compounds bearing common hydrophobic amino acid side chains, which are being evaluated for their effects on protein–protein interactions.
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