(3S)-3-(4-cyanophenyl)-N-methoxy-N-methyl-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)propanamide

Base Information

• Chemical Name: (3S)-3-(4-cyanophenyl)-N-methoxy-N-methyl-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)propanamide
• CAS No.: 1050618-82-0
• Molecular Formula: C₂₁H₂₀F₃N₃O₃
• Molecular Weight: 419.403
• Mol file: 1050618-82-0.mol

Synonyms:(3S)-3-(4-cyanophenyl)-N-methoxy-N-methyl-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)propanamide

Chemical Property of (3S)-3-(4-cyanophenyl)-N-methoxy-N-methyl-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S)-3-(4-cyanophenyl)-N-methoxy-N-methyl-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)propanamide

There total 3 articles about (3S)-3-(4-cyanophenyl)-N-methoxy-N-methyl-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H15N3O2 (1050618-86-4) + 3-(trifluoromethyl)phenylacetic acid (351-35-9) → (3S)-3-(4-cyanophenyl)-N-methoxy-N-methyl-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)propanamide (1050618-82-0)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate (1050618-80-8) → (3S)-3-(4-cyanophenyl)-N-methoxy-N-methyl-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)propanamide (1050618-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1.5 h

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(S)-3-(tert-butoxycarbonylamino)-3-(4-cyanophenyl)propanoic acid (500770-82-1,501015-22-1,282524-88-3) → (3S)-3-(4-cyanophenyl)-N-methoxy-N-methyl-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)propanamide (1050618-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / dichloromethane / 1.5 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

C₁₂H₁₅N₃O₂

3-(trifluoromethyl)phenylacetic acid

tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate

(S)-3-(tert-butoxycarbonylamino)-3-(4-cyanophenyl)propanoic acid

Downstream raw materials:

N-[(1S)-1-(4-cyanophenyl)-3-oxobutyl]-2-[3-(trifluoromethyl)phenyl]acetamide

4-{(2S)-4-methyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile

4-{(2S)-1,4-dimethyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile

(6S)-6-(4-cyanophenyl)-4-methyl-2-oxo-N-propan-2-yl-3-[3-(trifluoromethyl)-phenyl]-5,6-dihydropyridine-1-carboxamide