4-{(2S)-1,4-dimethyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile

Base Information

Chemical Name:4-{(2S)-1,4-dimethyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile
CAS No.:1050618-71-7
Molecular Formula:C₂₁H₁₇F₃N₂O
Molecular Weight:370.374
Hs Code.:

Synonyms:4-{(2S)-1,4-dimethyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile

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Chemical Property of 4-{(2S)-1,4-dimethyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile

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Technology Process of 4-{(2S)-1,4-dimethyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile

There total 7 articles about 4-{(2S)-1,4-dimethyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1050618-74-0
4-{(2S)-4-methyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile

: 74-88-4
methyl iodide

: 1050618-71-7
4-{(2S)-1,4-dimethyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 351-35-9
3-(trifluoromethyl)phenylacetic acid

: 1050618-71-7
4-{(2S)-1,4-dimethyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: tetrahydrofuran / 0.33 h / -78 °C

3: sodium methylate / ethanol / 4 h / 50 °C

4: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

With sodium methylate; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1050618-86-4
C₁₂H₁₅N₃O₂

: 1050618-71-7
4-{(2S)-1,4-dimethyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: tetrahydrofuran / 0.33 h / -78 °C

3: sodium methylate / ethanol / 4 h / 50 °C

4: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

With sodium methylate; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;