tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate

Base Information

Chemical Name:tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate
CAS No.:1050618-80-8
Molecular Formula:C₁₇H₂₃N₃O₄
Molecular Weight:333.387
Hs Code.:

Synonyms:tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate

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Chemical Property of tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate

Chemical Property:

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Technology Process of tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate

There total 1 articles about tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 500770-82-1,501015-22-1,282524-88-3
(S)-3-(tert-butoxycarbonylamino)-3-(4-cyanophenyl)propanoic acid

: 1050618-80-8
tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1050618-80-8
tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate

: 1050618-86-4
C₁₂H₁₅N₃O₂

Guidance literature:: tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate; With trifluoroacetic acid; In dichloromethane; for 1.5h;

With water; sodium carbonate; In ethyl acetate;

Reference yield:

: 1050618-80-8
tert-butyl {(1S)-1-(4-cyanophenyl)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate

: 1050618-74-0
4-{(2S)-4-methyl-6-oxo-5-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridin-2-yl}benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 1.5 h

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3: tetrahydrofuran / 0.33 h / -78 °C

4: sodium methylate / ethanol / 4 h / 50 °C

With sodium methylate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;