(S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-pentanoic acid phenethyl-amide

Base Information

Chemical Name:(S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-pentanoic acid phenethyl-amide
CAS No.:188290-14-4
Molecular Formula:C₁₉H₃₃NO₃Si
Molecular Weight:351.561
Hs Code.:

Synonyms:(S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-pentanoic acid phenethyl-amide

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Chemical Property of (S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-pentanoic acid phenethyl-amide

Chemical Property:

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Technology Process of (S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-pentanoic acid phenethyl-amide

There total 5 articles about (S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-pentanoic acid phenethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 188290-13-3
(S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-pentanoic acid phenethyl-amide

: 188290-14-4
(S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-pentanoic acid phenethyl-amide

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(97)00070-7

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 188290-14-4
(S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-pentanoic acid phenethyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

2: 73 percent / DDQ / CH₂Cl₂; H₂O / 1 h / Ambient temperature

With 1H-imidazole; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)00070-7

Reference yield:

: 64-04-0
phenethylamine

: 188290-14-4
(S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-pentanoic acid phenethyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / tetrahydrofuran / 90 h / Heating

2: 99 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

3: 73 percent / DDQ / CH₂Cl₂; H₂O / 1 h / Ambient temperature

With 1H-imidazole; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)00070-7