9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine

Base Information

• Chemical Name: 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine
• CAS No.: 76988-75-5
• Molecular Formula: C₂₀H₁₂Cl₂F₃N₃O
• Molecular Weight: 438.236
• Mol file: 76988-75-5.mol

Synonyms:9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine

Chemical Property of 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine

There total 2 articles about 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine (76988-73-3) + trifluoroacetic anhydride (407-25-0) → 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine (76988-75-5)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1021/jm00365a009

Reference yield:

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine (76988-39-1) → 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine (76988-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Zn, CH₃COOH / CH₂Cl₂ / 2 h / -30 °C

2: 50 percent / pyridine / CH₂Cl₂ / 1.5 h / 0 °C

With pyridine; acetic acid; zinc; In dichloromethane;

DOI:10.1021/jm00365a009

Reference yield: 21.0%

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine (76988-75-5) → 8-chloro-6-(2-chlorophenyl)-5-(trifluoroacetyl)-5,6-dihydro-4H-oxazolo<5,4-d><2>benzazepine (86709-93-5) + 9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine 3-oxide (76988-78-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 46h; Ambient temperature;

DOI:10.1021/jm00365a009

upstream raw materials:

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine

trifluoroacetic anhydride

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine

Downstream raw materials:

8-chloro-6-(2-chlorophenyl)-5-(trifluoroacetyl)-5,6-dihydro-4H-oxazolo<5,4-d><2>benzazepine

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine 3-oxide

5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime

9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide