N-(tert-butyloxycarbonyl)-2-phenethyl-5-carbethoxy-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-2-phenethyl-5-carbethoxy-1,2,3,6-tetrahydropyridine
CAS No.:134420-85-2
Molecular Formula:C₂₁H₂₉NO₄
Molecular Weight:359.466
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-2-phenethyl-5-carbethoxy-1,2,3,6-tetrahydropyridine

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Chemical Property of N-(tert-butyloxycarbonyl)-2-phenethyl-5-carbethoxy-1,2,3,6-tetrahydropyridine

Chemical Property:

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Technology Process of N-(tert-butyloxycarbonyl)-2-phenethyl-5-carbethoxy-1,2,3,6-tetrahydropyridine

There total 8 articles about N-(tert-butyloxycarbonyl)-2-phenethyl-5-carbethoxy-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 4-Acetoxy-6-phenethyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

: 134420-85-2
N-(tert-butyloxycarbonyl)-2-phenethyl-5-carbethoxy-1,2,3,6-tetrahydropyridine

Guidance literature:: With DBN; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1021/jm00112a032

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 134420-85-2
N-(tert-butyloxycarbonyl)-2-phenethyl-5-carbethoxy-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 5percent aq. potassium carbonate / dioxane / a) 0 deg C, 15 min, b) RT, 3 h

2: 80 percent / sodium / ethanol; benzene / 24 h / Ambient temperature

3: H₂ / 20percent Raney nickel / ethanol / 80 °C / 45600 Torr

4: Heating

5: 75 percent / 1,5-diazabicyclo<4.3.0>non-5-ene / tetrahydrofuran / 3 h / Ambient temperature

With DBN; hydrogen; sodium; potassium carbonate; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; benzene;
DOI:10.1021/jm00112a032

Reference yield:

: 134420-70-5
3-amino-5-phenyl-pentanoic acid ethyl ester

: 134420-85-2
N-(tert-butyloxycarbonyl)-2-phenethyl-5-carbethoxy-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / ethanol / Ambient temperature

2: 95 percent / 5percent aq. potassium carbonate / dioxane / a) 0 deg C, 15 min, b) RT, 3 h

3: 80 percent / sodium / ethanol; benzene / 24 h / Ambient temperature

4: H₂ / 20percent Raney nickel / ethanol / 80 °C / 45600 Torr

5: Heating

6: 75 percent / 1,5-diazabicyclo<4.3.0>non-5-ene / tetrahydrofuran / 3 h / Ambient temperature

With DBN; hydrogen; sodium; potassium carbonate; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; benzene;
DOI:10.1021/jm00112a032