3-(3-(bromomethyl)-2-ethylphenyl)-5-(4-isopropoxy-3-(trifluoromethyl)-phenyl)-1,2,4-thiadiazole

Base Information

• Chemical Name: 3-(3-(bromomethyl)-2-ethylphenyl)-5-(4-isopropoxy-3-(trifluoromethyl)-phenyl)-1,2,4-thiadiazole
• CAS No.: 1344997-55-2
• Molecular Formula: C₂₁H₂₀BrF₃N₂OS
• Molecular Weight: 485.368
• Mol file: 1344997-55-2.mol

Synonyms:3-(3-(bromomethyl)-2-ethylphenyl)-5-(4-isopropoxy-3-(trifluoromethyl)-phenyl)-1,2,4-thiadiazole

Chemical Property of 3-(3-(bromomethyl)-2-ethylphenyl)-5-(4-isopropoxy-3-(trifluoromethyl)-phenyl)-1,2,4-thiadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-(bromomethyl)-2-ethylphenyl)-5-(4-isopropoxy-3-(trifluoromethyl)-phenyl)-1,2,4-thiadiazole

There total 11 articles about 3-(3-(bromomethyl)-2-ethylphenyl)-5-(4-isopropoxy-3-(trifluoromethyl)-phenyl)-1,2,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H21F3N2O2S → 3-(3-(bromomethyl)-2-ethylphenyl)-5-(4-isopropoxy-3-(trifluoromethyl)-phenyl)-1,2,4-thiadiazole (1344997-55-2)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

4,4,5,5-tetramethyl-2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane (1334607-79-2) → 3-(3-(bromomethyl)-2-ethylphenyl)-5-(4-isopropoxy-3-(trifluoromethyl)-phenyl)-1,2,4-thiadiazole (1344997-55-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 1 h / 80 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

3: sodium tetrahydroborate; methanol / 0 - 20 °C

4: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; potassium phosphate; carbon tetrabromide; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki Coupling / 2: Suzuki Coupling;

Reference yield:

2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (1260023-43-5) → 3-(3-(bromomethyl)-2-ethylphenyl)-5-(4-isopropoxy-3-(trifluoromethyl)-phenyl)-1,2,4-thiadiazole (1344997-55-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

2: sodium tetrahydroborate; methanol / 0 - 20 °C

3: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; potassium phosphate; carbon tetrabromide; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki Coupling;

upstream raw materials:

1,3-dibromobenzene

1,3-dibromo-2-ethyl-benzene

3-bromo-2-ethylbenzaldehyde

2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

Downstream raw materials:

{1-[(2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}phenyl)methyl]-4-piperidinyl}acetic acid

2-((2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzyl)(methyl)amino)-2-methylpropanoic acid

C₂₉H₃₄F₃N₃O₃S