(S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone

Base Information

Chemical Name:(S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone
CAS No.:1013023-56-7
Molecular Formula:C₂₉H₂₆ClNO₄S
Molecular Weight:520.049
Hs Code.:

Synonyms:(S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone

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Chemical Property of (S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone

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Technology Process of (S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone

There total 2 articles about (S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 184764-13-4
[S-(E)]-1-[2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]-phenyl]-3-hydroxypropyl]phenyl]ethanone

: 1013023-56-7
(S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone

Guidance literature:: With triethylamine; In toluene; at -10 - -5 ℃; for 1h;

Reference yield:

: 149968-11-6
methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate

: 1013023-56-7
(S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: (-)-diisopinocamphenylborane chloride / dichloromethane / -5 - 0 °C

2: cerium(III) chloride / tetrahydrofuran / 0 - 5 °C

3: Alkaline conditions

With cerium(III) chloride; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; dichloromethane; 2: Grignard reaction;

Reference yield: 74.6%

: 1-(mercaptomethyl)cyclopropane acetic acid disodium salt

: 1013023-56-7
(S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone

: 101-83-7
N-cyclohexyl-cyclohexanamine

: 1013023-48-7
[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid dicyclohexyl amine salt

Guidance literature:: 1-(mercaptomethyl)cyclopropane acetic acid disodium salt; (S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone; at 5 - 25 ℃; for 15h;

With acetic acid; In water; pH=4.5 - 5.5;

N-cyclohexyl-cyclohexanamine; In acetone; at 20 - 25 ℃; for 2.58333h; Heating / reflux;