[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid dicyclohexyl amine salt

Base Information

• Chemical Name: [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid dicyclohexyl amine salt
• CAS No.: 1013023-48-7
• Molecular Formula: C₁₂H₂₃N*C₃₄H₃₂ClNO₃S
• Molecular Weight: 751.473
• Mol file: 1013023-48-7.mol

Synonyms:[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid dicyclohexyl amine salt

Chemical Property of [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid dicyclohexyl amine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid dicyclohexyl amine salt

There total 6 articles about [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid dicyclohexyl amine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

1-(mercaptomethyl)cyclopropane acetic acid disodium salt + (S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone (1013023-56-7) + N-cyclohexyl-cyclohexanamine (101-83-7) → [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid dicyclohexyl amine salt (1013023-48-7)

Guidance literature:

1-(mercaptomethyl)cyclopropane acetic acid disodium salt; (S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone; at 5 - 25 ℃; for 15h;

With acetic acid; In water; pH=4.5 - 5.5;

N-cyclohexyl-cyclohexanamine; In acetone; at 20 - 25 ℃; for 2.58333h; Heating / reflux;

Reference yield:

[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid (937275-23-5) + N-cyclohexyl-cyclohexanamine (101-83-7) → [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid dicyclohexyl amine salt (1013023-48-7)

Guidance literature:

In ethyl acetate; at 0 - 20 ℃; for 2h; Product distribution / selectivity;

Reference yield:

methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate (149968-11-6) → [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid dicyclohexyl amine salt (1013023-48-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: (-)-diisopinocamphenylborane chloride / dichloromethane / -5 - 0 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 5 °C

3.1: sodium methylate / methanol; N,N-dimethyl-formamide / 1.5 h / -5 - 0 °C

3.2: 19 h / 0 - 5 °C

4.1: tetrahydrofuran / 9 h / 0 - 5 °C

5.1: ethyl acetate / 6 h / 25 - 30 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 4.1: Grignard reaction;

upstream raw materials:

[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid

N-cyclohexyl-cyclohexanamine

(S)-(E)-1-(2-(1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-1-(methanesulfonyl-oxy)propyl)phenyl)ethanone

[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid