(2S^*,3S^*,4S^*)-4-Acetyl-3-<2-(tert-butyldimethylsiloxy)ethyl>-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine

Base Information

• Chemical Name: (2S^*,3S^*,4S^*)-4-Acetyl-3-<2-(tert-butyldimethylsiloxy)ethyl>-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine
• CAS No.: 137119-49-4
• Molecular Formula: C₂₄H₃₇NO₆Si
• Molecular Weight: 463.646

Synonyms:(2S^*,3S^*,4S^*)-4-Acetyl-3-<2-(tert-butyldimethylsiloxy)ethyl>-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine

Chemical Property of (2S^*,3S^*,4S^*)-4-Acetyl-3-<2-(tert-butyldimethylsiloxy)ethyl>-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S^*,3S^*,4S^*)-4-Acetyl-3-<2-(tert-butyldimethylsiloxy)ethyl>-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine

There total 5 articles about (2S^*,3S^*,4S^*)-4-Acetyl-3-<2-(tert-butyldimethylsiloxy)ethyl>-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

trans-3-Acetyl-4-<2-(tert-butyldimethylsiloxy)ethyl>-5-(methoxycarbonyl)-1-(phenoxyacetyl)-2-pyrroline (137007-48-8) → (2S*,3S*,4S*)-4-Acetyl-3-<2-(tert-butyldimethylsiloxy)ethyl>-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine (137119-49-4) + (2R,3R,4S)-4-Acetyl-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(2-phenoxy-acetyl)-pyrrolidine-2-carboxylic acid methyl ester (137007-47-7)

Guidance literature:

With hydrogen; Lindlar's catalyst; In ethyl acetate; Ambient temperature;

DOI:10.1021/jo00026a035

Reference yield:

phenoxyacetic anhydride (14316-61-1) → (2S*,3S*,4S*)-4-Acetyl-3-<2-(tert-butyldimethylsiloxy)ethyl>-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine (137119-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

2: 90 percent / H₂ / 5percent Pd/CaCO₃ / ethyl acetate / Ambient temperature

With hydrogen; triethylamine; Lindlar's catalyst; In dichloromethane; ethyl acetate;

DOI:10.1021/jo00026a035

Reference yield:

(E)-6-((tert-butyldimethylsilyl)oxy)hex-3-en-2-one (96429-43-5) → (2S*,3S*,4S*)-4-Acetyl-3-<2-(tert-butyldimethylsiloxy)ethyl>-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine (137119-49-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / TBAF / tetrahydrofuran / 1 h / -78 °C

2: 88 percent / MeOH / Zn(OAc)2 / dimethylsulfoxide / 55 °C

3: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

4: 90 percent / H₂ / 5percent Pd/CaCO₃ / ethyl acetate / Ambient temperature

With methanol; tetrabutyl ammonium fluoride; hydrogen; triethylamine; Lindlar's catalyst; zinc diacetate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate;

DOI:10.1021/jo00026a035

upstream raw materials:

trans-3-Acetyl-4-<2-(tert-butyldimethylsiloxy)ethyl>-5-(methoxycarbonyl)-1-(phenoxyacetyl)-2-pyrroline

phenoxyacetic anhydride

(E)-6-((tert-butyldimethylsilyl)oxy)hex-3-en-2-one

3-Acetyl-4-<2-(tert-butyldimethylsiloxy)ethyl>-5-(methylcarbonyl)-2-pyrroline

Downstream raw materials:

(2S^*,3S^*,4R^*)-3-<2-(tert-Butyldimethylsiloxy)ethyl>-4-isopropenyl-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine

(2S^*,3S^*,4R^*)-3-<2-Hydroxyethyl>-4-isopropenyl-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine

(2S^*,3S^*,4R^*)-3-(Carboxymethyl)-4-isopropenyl-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 137119-49-4 (2S^*,3S^*,4S^*)-4-Acetyl-3-<2-(tert-butyldimethylsiloxy)ethyl>-2-(methoxycarbonyl)-1-(phenoxyacetyl)pyrrolidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send