N-{5-[1-(3-aminopropyl)piperidin-4-yl]-2,4-difluorophenyl}isobutyramide

Base Information

Chemical Name:N-{5-[1-(3-aminopropyl)piperidin-4-yl]-2,4-difluorophenyl}isobutyramide
CAS No.:762300-01-6
Molecular Formula:C₁₈H₂₇F₂N₃O
Molecular Weight:339.429
Hs Code.:

Synonyms:N-{5-[1-(3-aminopropyl)piperidin-4-yl]-2,4-difluorophenyl}isobutyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{5-[1-(3-aminopropyl)piperidin-4-yl]-2,4-difluorophenyl}isobutyramide

Chemical Property:

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Technology Process of N-{5-[1-(3-aminopropyl)piperidin-4-yl]-2,4-difluorophenyl}isobutyramide

There total 8 articles about N-{5-[1-(3-aminopropyl)piperidin-4-yl]-2,4-difluorophenyl}isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 949096-74-6
N-(5-{1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]piperidin-4-yl}-2,4-difluorophenyl)isobutyramide

: 762300-01-6
N-{5-[1-(3-aminopropyl)piperidin-4-yl]-2,4-difluorophenyl}isobutyramide

Guidance literature:: With hydrazine hydrate; In ethanol; at 90 ℃; for 4h;
DOI:10.1021/jm060381c

Reference yield:

: 762298-01-1
tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylate

: 762300-01-6
N-{5-[1-(3-aminopropyl)piperidin-4-yl]-2,4-difluorophenyl}isobutyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 10343.2 Torr

2: 98 percent / HCl / dioxane / 1 h / 20 °C

3: Bu₄NI; EtN(i-Pr)2 / dioxane / 99 °C

4: H₂NNH₂*H₂O / ethanol / 4 h / 90 °C

With hydrogenchloride; hydrogen; tetra-(n-butyl)ammonium iodide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; ethyl acetate;
DOI:10.1021/jm060381c

Reference yield:

: 762297-97-2
N-(5-bromo-2,4-difluorophenyl)-2-methylpropanamide

: 762300-01-6
N-{5-[1-(3-aminopropyl)piperidin-4-yl]-2,4-difluorophenyl}isobutyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 59 percent / K₂CO₃ / PdCl₂dppf / dimethylformamide / 80 °C

2: 85 percent / H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 10343.2 Torr

3: 98 percent / HCl / dioxane / 1 h / 20 °C

4: Bu₄NI; EtN(i-Pr)2 / dioxane / 99 °C

5: H₂NNH₂*H₂O / ethanol / 4 h / 90 °C

With hydrogenchloride; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm060381c