2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one

Base Information

Chemical Name:2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one
CAS No.:1273388-39-8
Molecular Formula:C₂₁H₂₂F₃N₅O₃
Molecular Weight:449.433
Hs Code.:

Synonyms:2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one

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Chemical Property of 2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one

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Technology Process of 2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one

There total 7 articles about 2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1273316-04-3
2-(3-methoxypropyl)-9-methyl-7,9-dihydro-8H-purine-8-one

: 1273316-06-5
3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt

: 1273388-39-8
2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one

Guidance literature:: bis(trichloromethyl) carbonate; 3-[4-(trifluoromethyl)phenyl]azetidine trifluoroacetate salt; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

2-(3-methoxypropyl)-9-methyl-7,9-dihydro-8H-purine-8-one; With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 20 ℃; for 3h;

With hydrogenchloride; In methanol; at 20 ℃; for 0.166667h;

Reference yield:

: 1273315-11-9
2-chloro-9-methyl-7H-purin-8(9H)-one

: 1273388-39-8
2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide

2.1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾; XPhos / acetonitrile / 0.5 h / 120 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

5.2: 3 h / 20 °C

5.3: 0.17 h / 20 °C

With tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 89283-49-8
2-chloro-4-(methylamino)-5-nitropyrimidine

: 1273388-39-8
2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; ammonium chloride / iron / ethanol / 1 h / Reflux

2.1: tetrahydrofuran / 12 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide

4.1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾; XPhos / acetonitrile / 0.5 h / 120 °C / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / Reflux

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

7.2: 3 h / 20 °C

7.3: 0.17 h / 20 °C

With tetrabutyl ammonium fluoride; water; hydrogen; potassium carbonate; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; iron; XPhos; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;