(E)-2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)benzenamine

Base Information

Chemical Name:(E)-2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)benzenamine
CAS No.:1133966-14-9
Molecular Formula:C₂₅H₂₄N₄OS
Molecular Weight:428.558
Hs Code.:

Synonyms:(E)-2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)benzenamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)benzenamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)benzenamine

There total 7 articles about (E)-2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: (Ε)-6-iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

: 3292-42-0
2-aminobenzenethiol hydrochloride

: 1133966-14-9
(E)-2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)benzenamine

Guidance literature:: With sodium hydroxide; In ISOPROPYLAMIDE; at 155 ℃; Inert atmosphere;

Reference yield:

: 886230-75-7
(Ε)-6-nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

: 1133966-14-9
(E)-2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)benzenamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium chloride; iron / ethanol; water / 2 h / 50 °C

2.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0 °C

2.2: 2 h / 0 °C

3.1: sodium hydroxide / ISOPROPYLAMIDE / 155 °C / Inert atmosphere

With hydrogenchloride; iron; ammonium chloride; acetic acid; sodium hydroxide; sodium nitrite; In ethanol; ISOPROPYLAMIDE; water;

Reference yield:

: 1141-88-4
2-Aminophenyl disulfide

: 1133966-14-9
(E)-2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)benzenamine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; zinc / ethanol / 0.5 h

2: sodium hydroxide / ISOPROPYLAMIDE / 155 °C / Inert atmosphere

With hydrogenchloride; sodium hydroxide; zinc; In ethanol; ISOPROPYLAMIDE;