(E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenylamino)hexanoate

Base Information

Chemical Name:(E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenylamino)hexanoate
CAS No.:1133966-18-3
Molecular Formula:C₃₃H₃₆N₄O₄S
Molecular Weight:584.739
Hs Code.:

Synonyms:(E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenylamino)hexanoate

Suppliers and Price of (E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenylamino)hexanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenylamino)hexanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenylamino)hexanoate

There total 9 articles about (E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenylamino)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 626-86-8
adipinic acid monoethyl ester

: 1133966-14-9
(E)-2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)benzenamine

: 1133966-18-3
(E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenylamino)hexanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 123 ℃; Inert atmosphere;

Reference yield:

: 886230-75-7
(Ε)-6-nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

: 1133966-18-3
(E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenylamino)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium chloride; iron / ethanol; water / 2 h / 50 °C

2.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0 °C

2.2: 2 h / 0 °C

3.1: sodium hydroxide / ISOPROPYLAMIDE / 155 °C / Inert atmosphere

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 123 °C / Inert atmosphere

With hydrogenchloride; dmap; iron; ammonium chloride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; sodium nitrite; In ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 1141-88-4
2-Aminophenyl disulfide

: 1133966-18-3
(E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenylamino)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; zinc / ethanol / 0.5 h

2: sodium hydroxide / ISOPROPYLAMIDE / 155 °C / Inert atmosphere

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 123 °C / Inert atmosphere

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; In ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide;