3-[4-(dimethylamino)phenyl]-6,7-difluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one

Base Information

Chemical Name:3-[4-(dimethylamino)phenyl]-6,7-difluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS No.:1491155-36-2
Molecular Formula:C₁₆H₁₄F₂N₂O₂
Molecular Weight:304.296
Hs Code.:

Synonyms:3-[4-(dimethylamino)phenyl]-6,7-difluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one

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Chemical Property of 3-[4-(dimethylamino)phenyl]-6,7-difluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one

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Technology Process of 3-[4-(dimethylamino)phenyl]-6,7-difluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one

There total 3 articles about 3-[4-(dimethylamino)phenyl]-6,7-difluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.6%

: 158580-95-1
6,7-difluoro-1H-indole-2,3-dione

: 7353-91-5
4-dimethylaminophenylmagnesium bromide

: 1491155-36-2
3-[4-(dimethylamino)phenyl]-6,7-difluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere; Cooling with ice;
DOI:10.1016/j.ejmech.2013.08.030

Reference yield:

: 4519-40-8
2,3-difluoroanilline

: 1491155-36-2
3-[4-(dimethylamino)phenyl]-6,7-difluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium sulfate; hydroxylamine hydrochloride; hydrogenchloride / water

2: sulfuric acid / Heating

3: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

With hydrogenchloride; sulfuric acid; hydroxylamine hydrochloride; sodium sulfate; In tetrahydrofuran; water; 3: |Grignard Reaction;
DOI:10.1016/j.ejmech.2013.08.030

Reference yield:

: 170108-12-0
N-(2,3-difluorophenyl)-2-(hydroxyimino)acetamide

: 1491155-36-2
3-[4-(dimethylamino)phenyl]-6,7-difluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / Heating

2: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

With sulfuric acid; In tetrahydrofuran; 2: |Grignard Reaction;
DOI:10.1016/j.ejmech.2013.08.030