7353-91-5

Basic information

• Product Name: 4-(N,N-DIMETHYL)ANILINEMAGNESIUM BROMIDE
• Synonyms: 4-DIMETHYLAMINOPHENYLMAGNESIUM BROMIDE;4-(N,N-DIMETHYL)ANILINEMAGNESIUM BROMIDE;4-(N,N-DIMETHYL)ANILINEMAGNESIUM BROMIDE, 0.5M SOLUTION IN TETRAHYDROFURAN;4-Dimethylaminophenylmagnesium Bromide, 0.75 M In Tetrahydrofuran;4-(n,n-dimethyl)aniline magnesium bromide solution;4-(N,N-Dimethyl)aniline magnesium bromide solution 0.5 in THF;4-(N,N-Dimethyl)aniline magnesium bromide 0.5M in THF;4-(N,N-Dimethyl)anilinemagnesium bromide 0.5M solution in THF
• CAS NO: 7353-91-5
• Molecular Formula: C₈H₁₀BrMgN
• Molecular Weight: 224.38
• Product Categories: Aryl;Grignard Reagents;Organometallic Reagents;Chemical Synthesis;Grignard Reagents;Organometallic Reagents
• Mol File: 7353-91-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 53-54℃
• Boiling Point: 65 °C
• Flash Point: <1 °F
• Appearance: /
• Density: 0.951 g/mL at 25 °C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(N,N-DIMETHYL)ANILINEMAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(N,N-DIMETHYL)ANILINEMAGNESIUM BROMIDE(7353-91-5)
• EPA Substance Registry System: 4-(N,N-DIMETHYL)ANILINEMAGNESIUM BROMIDE(7353-91-5)

Safety Data

• Hazard Codes: F,C
• Statements: 11-14-19-22-34-40-37
• Safety Statements: 16-23-26-36/37/39-45
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• Hazardous Substances Data: 7353-91-5(Hazardous Substances Data)

Usage

Uses

Bromo(4-(dimethylamino)phenyl)magnesium is used in preparation of Penta-deuterium-substituted Malachite green salt.It is used in preparation of Triaryl Phosphine ligands and use in catalyzing coupling reactions.

InChI:InChI=1/C8H10N.BrH.Mg/c1-9(2)8-6-4-3-5-7-8;;/h4-7H,1-2H3;1H;/q;;+1/p-1/rC8H10BrMgN/c1-11(2)8-5-3-7(10-9)4-6-8/h3-6H,1-2H3

Upstream product

• 586-77-6 4-bromo-N,N-dimethylaniline 
• 7439-95-4 magnesium 

Downstream Products

• 848073-29-0 1-[(S)-2-(4-Dimethylamino-benzoyl)-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone 
• 849479-94-3 tert-butyl (2S)-2-[(1R)-1-(4-(dimethylamino)phenyl)-1-hydroxy-2-methoxyethyl]indoline-1-carboxylate 
• 84127-06-0 bis[4-(N,N-dimethylaminephenyl)]phosphine oxide 
• 10536-64-8 sym. Bis-<4-dimethylamino-phenyl>-tetramethyl-disilan 
• 2124-31-4 4'-dimethylaminoacetophenone 
• 51053-80-6 {p-(CH₃)2NC₆H₄}3SnC₆H₄-p-F 
• 28611-39-4 4-(dimethylamino)benzene-boronic acid 
• 107176-00-1 tris(4-dimethylamino phenyl)boroxine 
• 90624-53-6 C₅(CH₃)5RhP(CH₃)3(C₆H₄N(CH₃)2)Br 
• 82876-89-9 ((CH₃)2NC₆H₄)3B(OC₃HN₂(CH₃)2(C₆H₅)) 
• 79159-82-3 1,1-bis(p-dimethylaminophenyl)-2,3,4,5-tetraphenyl-1-germacyclopentadiene 
• 79411-48-6 1-chloro-1-p-dimethylaminophenyl-2,3,4,5-tetraphenyl-1-germacyclopentadiene 

Relevant articles and documents

Preparation method for bis[di-tert-butyl(4-dimethylaminophenyl)phosphine]dichloropalladium

The invention discloses a preparation method for bis[di-tert-butyl(4-dimethylaminophenyl)phosphine]dichloropalladium. The preparation method comprises the following steps that 1, a Grignard reagent isprepared from the raw materials of N, N-dimethyl p-haloaniline and magnesium chips; 2, the Grignard reagent is taken and cooled, then a catalyst is added for reaction, then di-tert-butylchlorophosphane is dropwise added, and heating is carried out for reaction so as to obtain di-tert-butyl-4-dimethylaminophenylphosphine; 3, the di-tert-butyl-4-dimethylaminophenylphosphine is purified; and 4, complexing bis(acetonitrile)dichloropalladium and the purified di-tert-butyl-4-dimethylaminophenylphosphine so as to obtain a target product. The preparation method has the advantages that the di-tert-butyl-4-dimethylaminophenylphosphine is purified, the high-purity di-tert-butyl-4-dimethylaminophenylphosphine is used for reacting with the bis(acetonitrile)dichloropalladium, and therefore the yield loss of the noble metal palladium is greatly reduced, the preparation cost is greatly lowered, and the method has a good practical value.

Selective introducing of aryl and amino groups: Reaction of benzanthrone and organometallic reagents

The reaction of benzanthrone and aryl magnesium bromides produced 6-aryl-substituted benzanthrones in moderate to good yields. Similarly, 6-alkylaminobenzanthrones were selectively prepared by the reaction of benzanthrone and lithium alkylamides. In contrast, for the lithium arylamides, the arylamino groups were selectively introduced at the 4-position of the benzanthrone.

CATALYTIC RADIOFLUORINATION

One aspect of the present invention relates to a method of preparing radio fluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to arylammonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the ammonium compound is a tetraaryl ammonium salt. Another aspect of the invention relates to arylsulfonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the sulfonium compound is a triaryl sulfonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.