2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-4-methyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

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Chemical Name:2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-4-methyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide
CAS No.:1301660-52-5
Molecular Formula:C₃₁H₃₀F₇N₃O₃
Molecular Weight:625.586
Hs Code.:

2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-4-methyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Synonyms:2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-4-methyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

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Chemical Property of 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-4-methyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

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Technology Process of 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-4-methyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

There total 10 articles about 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-4-methyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1301661-10-8
methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate

: 1301660-52-5
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-4-methyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Guidance literature:: methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate; With sodium tetrahydroborate; calcium chloride; In methanol; for 3h; Cooling with ice;

With hydrogenchloride; In methanol; water;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-52-5
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-4-methyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

5.1: hydrogen / Raney-Ni / ethanol; water / 4 h

6.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

7.2: 0.25 h / -78 °C

8.1: sodium hydride / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

8.2: 1 h / 0 °C

9.1: trifluoroacetic acid / dichloromethane / 2 h

10.1: calcium chloride; sodium tetrahydroborate / methanol / 3 h / Cooling with ice

With dmap; sodium tetrahydroborate; osmium(VIII) oxide; water; hydrogen; sodium hydride; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; calcium chloride; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-56-9
2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-formyl-3-pyridinyl]-N,2-dimethylpropanamide

: 1301660-52-5
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-4-methyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene / 2 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

3.1: hydrogen / Raney-Ni / ethanol; water / 4 h

4.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

5.2: 0.25 h / -78 °C

6.1: sodium hydride / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

6.2: 1 h / 0 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h

8.1: calcium chloride; sodium tetrahydroborate / methanol / 3 h / Cooling with ice

With dmap; sodium tetrahydroborate; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; calcium chloride; lithium hexamethyldisilazane; Raney-Ni; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;