methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate

Base Information

Chemical Name:methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate
CAS No.:1301661-10-8
Molecular Formula:C₃₂H₃₀F₇N₃O₄
Molecular Weight:653.597
Hs Code.:

methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate

Synonyms:methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate

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Chemical Property of methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate

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Technology Process of methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate

There total 9 articles about methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1301661-08-4
1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-1,3-pyrrolidinedicarboxylate

: 1301661-10-8
methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate

Guidance literature:: 1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-1,3-pyrrolidinedicarboxylate; With trifluoroacetic acid; In dichloromethane; for 2h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301661-10-8
methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

5.1: hydrogen / Raney-Ni / ethanol; water / 4 h

6.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

7.2: 0.25 h / -78 °C

8.1: sodium hydride / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

8.2: 1 h / 0 °C

9.1: trifluoroacetic acid / dichloromethane / 2 h

With dmap; osmium(VIII) oxide; water; hydrogen; sodium hydride; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-56-9
2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-formyl-3-pyridinyl]-N,2-dimethylpropanamide

: 1301661-10-8
methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-methyl-2-oxo-3-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 2 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

3.1: hydrogen / Raney-Ni / ethanol; water / 4 h

4.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

5.2: 0.25 h / -78 °C

6.1: sodium hydride / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

6.2: 1 h / 0 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h

With dmap; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; Raney-Ni; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;