4-{[(1S,2R)-2-(tert-Butyldiphenylsilyloxymethyl)-1-(3-fluorophenyl)cyclopropyl]methoxy}-1-ethyl-3-methyl-1H-pyrazole

Base Information

Chemical Name:4-{[(1S,2R)-2-(tert-Butyldiphenylsilyloxymethyl)-1-(3-fluorophenyl)cyclopropyl]methoxy}-1-ethyl-3-methyl-1H-pyrazole
CAS No.:1383747-11-2
Molecular Formula:C₃₃H₃₉FN₂O₂Si
Molecular Weight:542.769
Hs Code.:

Synonyms:4-{[(1S,2R)-2-(tert-Butyldiphenylsilyloxymethyl)-1-(3-fluorophenyl)cyclopropyl]methoxy}-1-ethyl-3-methyl-1H-pyrazole

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Chemical Property of 4-{[(1S,2R)-2-(tert-Butyldiphenylsilyloxymethyl)-1-(3-fluorophenyl)cyclopropyl]methoxy}-1-ethyl-3-methyl-1H-pyrazole

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Technology Process of 4-{[(1S,2R)-2-(tert-Butyldiphenylsilyloxymethyl)-1-(3-fluorophenyl)cyclopropyl]methoxy}-1-ethyl-3-methyl-1H-pyrazole

There total 4 articles about 4-{[(1S,2R)-2-(tert-Butyldiphenylsilyloxymethyl)-1-(3-fluorophenyl)cyclopropyl]methoxy}-1-ethyl-3-methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383746-99-3
1-ethyl-3-methyl-1H-pyrazol-4-ol

: 1369767-21-4
{(1S,2R)-[2-(tert-butyldiphenylsilyloxymethyl)-1-(3-fluorophenyl)cyclopropyl]}methanol

: 1383747-11-2
4-{[(1S,2R)-2-(tert-Butyldiphenylsilyloxymethyl)-1-(3-fluorophenyl)cyclopropyl]methoxy}-1-ethyl-3-methyl-1H-pyrazole

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 35 ℃; for 20h;

Reference yield:

: 501-00-8
3-fluorophenylacetonitrile

: 1383747-11-2
4-{[(1S,2R)-2-(tert-Butyldiphenylsilyloxymethyl)-1-(3-fluorophenyl)cyclopropyl]methoxy}-1-ethyl-3-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / Cooling with ice-salt

1.2: 16 h / 0 - 35 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 65 h / 0 - 35 °C

2.2: Cooling with ice

3.1: triethylamine / dichloromethane / 21.5 h / -20 - 35 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 h / 0 - 35 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; sodium hexamethyldisilazane; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 4.1: Mitsunobu reaction;

Reference yield:

: 528587-70-4
(1S,5R)-2-oxo-1-(3-fluorophenyl)-3-oxabicyclo[3.1.0]hexane

: 1383747-11-2
4-{[(1S,2R)-2-(tert-Butyldiphenylsilyloxymethyl)-1-(3-fluorophenyl)cyclopropyl]methoxy}-1-ethyl-3-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 65 h / 0 - 35 °C

1.2: Cooling with ice

2.1: triethylamine / dichloromethane / 21.5 h / -20 - 35 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 h / 0 - 35 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 3.1: Mitsunobu reaction;