(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Base Information

Chemical Name:(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate
CAS No.:1411940-98-1
Molecular Formula:C₂₉H₃₈N₂O₆
Molecular Weight:510.631
Hs Code.:

Synonyms:(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Suppliers and Price of (S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

There total 9 articles about (S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093192-07-4
(S)-2-amino-3-(tert-butoxycarbonylamino)-3-methylbutanoic acid methyl ester

: 1410810-76-2
4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzoic acid

: 1411940-98-1
(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 1411940-98-1
(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 3 h / 0 - 15 °C

2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - 20 °C

3.1: potassium carbonate; methanol / 15 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

5.2: pH 4

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C

With methanol; oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 619-81-8,619-82-9,1076-97-7
cyclohexane-1,4-dicarboxylic acid

: 1411940-98-1
(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; thionyl chloride / methanol / 1 h / Cooling with ice; Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 3 h / 0 - 15 °C

4.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - 20 °C

5.1: potassium carbonate; methanol / 15 h / 0 - 20 °C

6.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

7.2: pH 4

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C

With hydrogenchloride; methanol; lithium aluminium tetrahydride; thionyl chloride; oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;