Technology Process of (S)-methyl 3-amino-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride
There total 10 articles about (S)-methyl 3-amino-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
methanol;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / tetrahydrofuran / 3 h / 0 - 15 °C
2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - 20 °C
3.1: potassium carbonate; methanol / 15 h / 0 - 20 °C
4.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere
5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C
5.2: pH 4
6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C
7.1: hydrogenchloride / methanol / 20 °C
With
hydrogenchloride; methanol; oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU;
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: hydrogenchloride; thionyl chloride / methanol / 1 h / Cooling with ice; Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
3.1: sodium hydride / tetrahydrofuran / 3 h / 0 - 15 °C
4.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - 20 °C
5.1: potassium carbonate; methanol / 15 h / 0 - 20 °C
6.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere
7.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C
7.2: pH 4
8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C
9.1: hydrogenchloride / methanol / 20 °C
With
hydrogenchloride; methanol; lithium aluminium tetrahydride; thionyl chloride; oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU;
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
