(S)-methyl 3-amino-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

Base Information

Chemical Name:(S)-methyl 3-amino-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride
CAS No.:1411941-02-0
Molecular Formula:C₂₄H₃₀N₂O₄*ClH
Molecular Weight:446.974
Hs Code.:

Synonyms:(S)-methyl 3-amino-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

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Chemical Property of (S)-methyl 3-amino-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

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Technology Process of (S)-methyl 3-amino-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

There total 10 articles about (S)-methyl 3-amino-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1411940-98-1
(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

: 1411941-02-0
(S)-methyl 3-amino-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃;

Reference yield:

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 1411941-02-0
(S)-methyl 3-amino-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 3 h / 0 - 15 °C

2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - 20 °C

3.1: potassium carbonate; methanol / 15 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

5.2: pH 4

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C

7.1: hydrogenchloride / methanol / 20 °C

With hydrogenchloride; methanol; oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 619-81-8,619-82-9,1076-97-7
cyclohexane-1,4-dicarboxylic acid

: 1411941-02-0
(S)-methyl 3-amino-2-(4-((4-(hydroxymethyl)cyclohexyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride; thionyl chloride / methanol / 1 h / Cooling with ice; Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 3 h / 0 - 15 °C

4.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - 20 °C

5.1: potassium carbonate; methanol / 15 h / 0 - 20 °C

6.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

7.2: pH 4

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 5 h / 20 °C

9.1: hydrogenchloride / methanol / 20 °C

With hydrogenchloride; methanol; lithium aluminium tetrahydride; thionyl chloride; oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;