6-(4-chlorophenyl)-3-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

Base Information

Chemical Name:6-(4-chlorophenyl)-3-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
CAS No.:1221419-54-0
Molecular Formula:C₂₂H₂₀ClN₅O₂
Molecular Weight:421.886
Hs Code.:

Synonyms:6-(4-chlorophenyl)-3-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

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Chemical Property of 6-(4-chlorophenyl)-3-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

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Technology Process of 6-(4-chlorophenyl)-3-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

There total 9 articles about 6-(4-chlorophenyl)-3-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1221420-36-5
4-(4-chlorophenyl)-1-((dimethylamino)methyleneamino)-N-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)-1H-pyrrole-2-carboxamide

: 1221419-54-0
6-(4-chlorophenyl)-3-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

Guidance literature:: With acetic acid; In acetonitrile; at 160 ℃; for 1h; Irradiation;

Reference yield:

: C₂₄H₂₇ClN₆O₂

: 1221419-54-0
6-(4-chlorophenyl)-3-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

Guidance literature:: With acetic acid; In acetonitrile; at 160 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.bmcl.2015.09.018

Reference yield:

: 1208361-39-0
1-amino-4-bromo-1H-pyrrole-2-carboxylic acid methyl ester

: 1221419-54-0
6-(4-chlorophenyl)-3-(6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 3 h / 60 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; tetra(n-butyl)ammonium hydroxide / toluene; water / 90 °C

3: lithium hydroxide / water; tetrahydrofuran / 60 °C

4: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 20 °C

5: acetic acid / acetonitrile / 1 h / 160 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetra(n-butyl)ammonium hydroxide; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; acetonitrile; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2015.09.018