5'-dimethoxytrityl-N₄-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine

Base Information

• Chemical Name: 5'-dimethoxytrityl-N₄-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine
• CAS No.: 159550-20-6
• Molecular Formula: C₄₈H₆₆N₆O₈P
• Molecular Weight: 886.061

Synonyms:5'-dimethoxytrityl-N₄-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine

Chemical Property of 5'-dimethoxytrityl-N₄-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-dimethoxytrityl-N₄-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine

There total 12 articles about 5'-dimethoxytrityl-N₄-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

bis(2-cyanoethyl diisopropylphosphoramidite) + 5'-dimethoxytrityl-N4-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine (342630-78-8) → 5'-dimethoxytrityl-N4-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine (159550-20-6)

Guidance literature:

With 1H-tetrazole; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm101232t

Reference yield: 51.0%

5'-dimethoxytrityl-N4-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine (342630-78-8) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → 5'-dimethoxytrityl-N4-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine (159550-20-6)

Guidance literature:

5'-dimethoxytrityl-N₄-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine; With Ν,Ν-diisopropylamine tetrazonide; for 16h; Reduced pressure;

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite; In dichloromethane; at 22 ℃; for 10h;

DOI:10.1021/ja905623k

Reference yield:

4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE (36768-62-4) → 5'-dimethoxytrityl-N4-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine (159550-20-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 0 - 20 °C

2: sodium tungstate; dihydrogen peroxide; ethylene diamine tetraacetic acid tetrasodium salt; sodium carbonate / water / 0 - 20 °C

3: potassium hydroxide / water / 36 h / Reflux

4: dichloromethane / 16 h / Reflux

5: ammonium hydroxide / methanol / 4 h / 20 °C

6: pyridine; dmap / 16 h / 20 °C / Inert atmosphere

7: 1H-tetrazole / acetonitrile / 2 h / 20 °C / Inert atmosphere

With pyridine; 1H-tetrazole; dmap; ammonium hydroxide; sodium tungstate; dihydrogen peroxide; ethylene diamine tetraacetic acid tetrasodium salt; sodium carbonate; potassium hydroxide; In methanol; dichloromethane; water; acetonitrile;

DOI:10.1021/jm101232t

upstream raw materials:

5'-dimethoxytrityl-N₄-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE

tempamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 159550-20-6 5'-dimethoxytrityl-N₄-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-2'-deoxycytidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send