3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-fluoro-1,2,3,4-tetrahydro-quinoline

Base Information

Chemical Name:3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-fluoro-1,2,3,4-tetrahydro-quinoline
CAS No.:849799-40-2
Molecular Formula:C₃₆H₅₁F₂NO₂Si₂
Molecular Weight:623.974
Hs Code.:

3-[3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-6-fluoro-1,2,3,4-tetrahydro-quinoline

Synonyms:3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-fluoro-1,2,3,4-tetrahydro-quinoline

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Chemical Property of 3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-fluoro-1,2,3,4-tetrahydro-quinoline

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Technology Process of 3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-fluoro-1,2,3,4-tetrahydro-quinoline

There total 4 articles about 3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-fluoro-1,2,3,4-tetrahydro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 849799-39-9
3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(4-fluoro-phenyl)-azetidin-2-one

: 849799-40-2
3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-fluoro-1,2,3,4-tetrahydro-quinoline

Guidance literature:: With aluminum (III) chloride; lithium aluminium tetrahydride; In diethyl ether; for 0.666667h; Heating / reflux;

3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(4-fluoro-phenyl)-azetidin-2-one; In diethyl ether; at 0 ℃; for 0.5h;

Reference yield: 63.0%

: 849799-39-9
3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(4-fluoro-phenyl)-azetidin-2-one

: C₂₉H₄₅FO₂Si₂

: 849799-40-2
3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-fluoro-1,2,3,4-tetrahydro-quinoline

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether; at 0 ℃; for 0.5h;
DOI:10.1021/ol0502127

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 849799-40-2
3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-fluoro-1,2,3,4-tetrahydro-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / imidazole / dimethylformamide / 5 h

2: 63 percent / LiAlH₄; AlCl₃ / diethyl ether / 0.5 h / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ol0502127