(S)-4-benzyl-3-[(4S,5S)-5-(3,4-dimethoxyphenyl)-5-(triisopropylsilyloxy)-4-(trityloxymethyl)pentanoyl]-2-oxazolidinone

Base Information

Chemical Name:(S)-4-benzyl-3-[(4S,5S)-5-(3,4-dimethoxyphenyl)-5-(triisopropylsilyloxy)-4-(trityloxymethyl)pentanoyl]-2-oxazolidinone
CAS No.:934219-71-3
Molecular Formula:C₅₂H₆₃NO₇Si
Molecular Weight:842.16
Hs Code.:

Synonyms:(S)-4-benzyl-3-[(4S,5S)-5-(3,4-dimethoxyphenyl)-5-(triisopropylsilyloxy)-4-(trityloxymethyl)pentanoyl]-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-benzyl-3-[(4S,5S)-5-(3,4-dimethoxyphenyl)-5-(triisopropylsilyloxy)-4-(trityloxymethyl)pentanoyl]-2-oxazolidinone

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Technology Process of (S)-4-benzyl-3-[(4S,5S)-5-(3,4-dimethoxyphenyl)-5-(triisopropylsilyloxy)-4-(trityloxymethyl)pentanoyl]-2-oxazolidinone

There total 8 articles about (S)-4-benzyl-3-[(4S,5S)-5-(3,4-dimethoxyphenyl)-5-(triisopropylsilyloxy)-4-(trityloxymethyl)pentanoyl]-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 934219-68-8
(S)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexen-1-ol

: 934219-71-3
(S)-4-benzyl-3-[(4S,5S)-5-(3,4-dimethoxyphenyl)-5-(triisopropylsilyloxy)-4-(trityloxymethyl)pentanoyl]-2-oxazolidinone

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / DMAP; pyridine / 16 h / 60 °C

2: 4-methylmorpholine N-oxide; OsO₄ / acetone; 2-methyl-propan-2-ol; H₂O / 16 h / 20 °C

3: NaIO₄ / methanol / 3 h / 20 °C

4: 16.8 g / 2-methyl-2-butene; NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 1 h / 20 °C

5: Et₃N / tetrahydrofuran / 1 h / 0 °C

6: 18.6 g / tetrahydrofuran / 1 h / 0 °C

With pyridine; dmap; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; water; acetone; tert-butyl alcohol;
DOI:10.1021/np060461j

Reference yield:

: 934219-69-9
(5S,6S)-6-(3,4-dimethoxyphenyl)-6-(triisopropylsilyloxy)-5-trityloxymethyl-1-hexene

: 934219-71-3
(S)-4-benzyl-3-[(4S,5S)-5-(3,4-dimethoxyphenyl)-5-(triisopropylsilyloxy)-4-(trityloxymethyl)pentanoyl]-2-oxazolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methylmorpholine N-oxide; OsO₄ / acetone; 2-methyl-propan-2-ol; H₂O / 16 h / 20 °C

2: NaIO₄ / methanol / 3 h / 20 °C

3: 16.8 g / 2-methyl-2-butene; NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 1 h / 20 °C

4: Et₃N / tetrahydrofuran / 1 h / 0 °C

5: 18.6 g / tetrahydrofuran / 1 h / 0 °C

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; water; acetone; tert-butyl alcohol;
DOI:10.1021/np060461j

Reference yield:

: C₄₂H₅₆O₅Si

: 934219-71-3
(S)-4-benzyl-3-[(4S,5S)-5-(3,4-dimethoxyphenyl)-5-(triisopropylsilyloxy)-4-(trityloxymethyl)pentanoyl]-2-oxazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: NaIO₄ / methanol / 3 h / 20 °C

2: 16.8 g / 2-methyl-2-butene; NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 1 h / 20 °C

3: Et₃N / tetrahydrofuran / 1 h / 0 °C

4: 18.6 g / tetrahydrofuran / 1 h / 0 °C

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; triethylamine; In tetrahydrofuran; methanol; water; tert-butyl alcohol;
DOI:10.1021/np060461j