(S)-2-[(2S,3S)-3-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)-2-(trityloxymethyl)prop-1-yl]-4-penten-1-ol

Base Information

Chemical Name:(S)-2-[(2S,3S)-3-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)-2-(trityloxymethyl)prop-1-yl]-4-penten-1-ol
CAS No.:934219-73-5
Molecular Formula:C₄₅H₆₀O₅Si
Molecular Weight:709.054
Hs Code.:

Synonyms:(S)-2-[(2S,3S)-3-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)-2-(trityloxymethyl)prop-1-yl]-4-penten-1-ol

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Chemical Property of (S)-2-[(2S,3S)-3-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)-2-(trityloxymethyl)prop-1-yl]-4-penten-1-ol

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Technology Process of (S)-2-[(2S,3S)-3-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)-2-(trityloxymethyl)prop-1-yl]-4-penten-1-ol

There total 10 articles about (S)-2-[(2S,3S)-3-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)-2-(trityloxymethyl)prop-1-yl]-4-penten-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 934219-72-4
(S)-4-benzyl-3-{(S)-2-[(2S,3S)-3-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)-2-(trityloxymethyl)prop-1-yl]-4-pentenoyl}-2-oxazolidinone

: 934219-73-5
(S)-2-[(2S,3S)-3-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)-2-(trityloxymethyl)prop-1-yl]-4-penten-1-ol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; methanol; at 20 ℃; for 1h;
DOI:10.1021/np060461j

Reference yield:

: 934219-68-8
(S)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexen-1-ol

: 934219-73-5
(S)-2-[(2S,3S)-3-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)-2-(trityloxymethyl)prop-1-yl]-4-penten-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / DMAP; pyridine / 16 h / 60 °C

2: 4-methylmorpholine N-oxide; OsO₄ / acetone; 2-methyl-propan-2-ol; H₂O / 16 h / 20 °C

3: NaIO₄ / methanol / 3 h / 20 °C

4: 16.8 g / 2-methyl-2-butene; NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 1 h / 20 °C

5: Et₃N / tetrahydrofuran / 1 h / 0 °C

6: 18.6 g / tetrahydrofuran / 1 h / 0 °C

7: 50 percent / KHMDS / toluene; tetrahydrofuran / 16 h / -70 - 20 °C

8: 89 percent / LiBH₄ / methanol; tetrahydrofuran / 1 h / 20 °C

With pyridine; dmap; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; lithium borohydride; 2-methyl-but-2-ene; potassium hexamethylsilazane; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; water; acetone; toluene; tert-butyl alcohol;
DOI:10.1021/np060461j

Reference yield:

: 934219-69-9
(5S,6S)-6-(3,4-dimethoxyphenyl)-6-(triisopropylsilyloxy)-5-trityloxymethyl-1-hexene

: 934219-73-5
(S)-2-[(2S,3S)-3-(3,4-dimethoxyphenyl)-3-(triisopropylsilyloxy)-2-(trityloxymethyl)prop-1-yl]-4-penten-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 4-methylmorpholine N-oxide; OsO₄ / acetone; 2-methyl-propan-2-ol; H₂O / 16 h / 20 °C

2: NaIO₄ / methanol / 3 h / 20 °C

3: 16.8 g / 2-methyl-2-butene; NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 1 h / 20 °C

4: Et₃N / tetrahydrofuran / 1 h / 0 °C

5: 18.6 g / tetrahydrofuran / 1 h / 0 °C

6: 50 percent / KHMDS / toluene; tetrahydrofuran / 16 h / -70 - 20 °C

7: 89 percent / LiBH₄ / methanol; tetrahydrofuran / 1 h / 20 °C

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; lithium borohydride; 2-methyl-but-2-ene; potassium hexamethylsilazane; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; water; acetone; toluene; tert-butyl alcohol;
DOI:10.1021/np060461j