(5S,6S)-6-(3,4-dimethoxyphenyl)-6-(triisopropylsilyloxy)-5-trityloxymethyl-1-hexene

Base Information

Chemical Name:(5S,6S)-6-(3,4-dimethoxyphenyl)-6-(triisopropylsilyloxy)-5-trityloxymethyl-1-hexene
CAS No.:934219-69-9
Molecular Formula:C₄₃H₅₆O₄Si
Molecular Weight:665.001
Hs Code.:

Synonyms:(5S,6S)-6-(3,4-dimethoxyphenyl)-6-(triisopropylsilyloxy)-5-trityloxymethyl-1-hexene

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Chemical Property of (5S,6S)-6-(3,4-dimethoxyphenyl)-6-(triisopropylsilyloxy)-5-trityloxymethyl-1-hexene

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Technology Process of (5S,6S)-6-(3,4-dimethoxyphenyl)-6-(triisopropylsilyloxy)-5-trityloxymethyl-1-hexene

There total 7 articles about (5S,6S)-6-(3,4-dimethoxyphenyl)-6-(triisopropylsilyloxy)-5-trityloxymethyl-1-hexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 934219-68-8
(S)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexen-1-ol

: 76-83-5
trityl chloride

: 934219-69-9
(5S,6S)-6-(3,4-dimethoxyphenyl)-6-(triisopropylsilyloxy)-5-trityloxymethyl-1-hexene

Guidance literature:: With pyridine; dmap; at 60 ℃; for 16h;
DOI:10.1021/np060461j

Reference yield:

: 934219-66-6
(S)-4-benzyl-3-{(R)-2-[(S)-(hydroxy)(3,4-dimethoxyphenyl)methyl]-5-hexenoyl}-2-oxazolidinone

: 934219-69-9
(5S,6S)-6-(3,4-dimethoxyphenyl)-6-(triisopropylsilyloxy)-5-trityloxymethyl-1-hexene

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / 2,6-litidine / CH₂Cl₂ / 1 h / 20 °C

2: 60 percent / LiBH₄ / methanol; tetrahydrofuran / 6 h / 20 °C

3: 81 percent / DMAP; pyridine / 16 h / 60 °C

With pyridine; 2,6-dimethylpyridine; dmap; lithium borohydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/np060461j

Reference yield:

: 934219-67-7
(S)-4-benzyl-3-{(R)-2-[(S)-(3,4-dimethoxyphenyl)(triisopropylsilyloxy)methyl]-5-hexenoyl}-2-oxazolidinone

: 934219-69-9
(5S,6S)-6-(3,4-dimethoxyphenyl)-6-(triisopropylsilyloxy)-5-trityloxymethyl-1-hexene

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / LiBH₄ / methanol; tetrahydrofuran / 6 h / 20 °C

2: 81 percent / DMAP; pyridine / 16 h / 60 °C

With pyridine; dmap; lithium borohydride; In tetrahydrofuran; methanol;
DOI:10.1021/np060461j