2-tert-butoxycarbonylamino-3-[5,6-dichloro-1-(dimethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid benzyl ester

Base Information

Chemical Name:2-tert-butoxycarbonylamino-3-[5,6-dichloro-1-(dimethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid benzyl ester
CAS No.:1027445-61-9
Molecular Formula:C₂₅H₃₀Cl₂N₃O₇P
Molecular Weight:586.409
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-3-[5,6-dichloro-1-(dimethoxy-phosphorylmethyl)-1<i>H</i>-benzoimidazol-2-yl]-propionic acid benzyl ester

Synonyms:2-tert-butoxycarbonylamino-3-[5,6-dichloro-1-(dimethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid benzyl ester

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Chemical Property of 2-tert-butoxycarbonylamino-3-[5,6-dichloro-1-(dimethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid benzyl ester

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Technology Process of 2-tert-butoxycarbonylamino-3-[5,6-dichloro-1-(dimethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid benzyl ester

There total 4 articles about 2-tert-butoxycarbonylamino-3-[5,6-dichloro-1-(dimethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96851-20-6
trifluoromethanesulfonic acid-[dimethoxyphosphinyl]-methyl ester

: 2-tert-butoxycarbonylamino-3-(5,6-dichloro-1H-benzoimidazol-2-yl)-propionic acid benzyl ester

: 1027445-61-9
2-tert-butoxycarbonylamino-3-[5,6-dichloro-1-(dimethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid benzyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃;
DOI:10.1021/jm000385w

Reference yield:

: 5348-42-5
4,5-Dichloro-1,2-phenylenediamine

: 1027445-61-9
2-tert-butoxycarbonylamino-3-[5,6-dichloro-1-(dimethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; ethyl chloroformate / tetrahydrofuran / 0.17 h / -10 °C

1.2: tetrahydrofuran / -10 - 20 °C

2.1: glacial acetic acid / 6 h / 70 - 75 °C

3.1: K₂CO₃ / acetonitrile / 20 °C

With chloroformic acid ethyl ester; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm000385w

Reference yield:

: 30925-18-9
2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester

: 1027445-61-9
2-tert-butoxycarbonylamino-3-[5,6-dichloro-1-(dimethoxy-phosphorylmethyl)-1H-benzoimidazol-2-yl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; ethyl chloroformate / tetrahydrofuran / 0.17 h / -10 °C

1.2: tetrahydrofuran / -10 - 20 °C

2.1: glacial acetic acid / 6 h / 70 - 75 °C

3.1: K₂CO₃ / acetonitrile / 20 °C

With chloroformic acid ethyl ester; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm000385w