benzyl 2-[2-(methoxycarbonyl)ethyl]-5-{(1S)-1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-phenylethyl}-1,3-oxazole-4-carboxylate

Base Information

Chemical Name:benzyl 2-[2-(methoxycarbonyl)ethyl]-5-{(1S)-1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-phenylethyl}-1,3-oxazole-4-carboxylate
CAS No.:628314-77-2
Molecular Formula:C₃₈H₃₄N₂O₇
Molecular Weight:630.697
Hs Code.:

Synonyms:benzyl 2-[2-(methoxycarbonyl)ethyl]-5-{(1S)-1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-phenylethyl}-1,3-oxazole-4-carboxylate

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Chemical Property of benzyl 2-[2-(methoxycarbonyl)ethyl]-5-{(1S)-1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-phenylethyl}-1,3-oxazole-4-carboxylate

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Technology Process of benzyl 2-[2-(methoxycarbonyl)ethyl]-5-{(1S)-1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-phenylethyl}-1,3-oxazole-4-carboxylate

There total 6 articles about benzyl 2-[2-(methoxycarbonyl)ethyl]-5-{(1S)-1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-phenylethyl}-1,3-oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 628314-75-0
benzyl (4S)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-{[3-(methoxycarbonyl)propanoyl]amino}-3-oxo-5-phenylpentanoate

: 628314-77-2
benzyl 2-[2-(methoxycarbonyl)ethyl]-5-{(1S)-1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-phenylethyl}-1,3-oxazole-4-carboxylate

Guidance literature:: With iodine; triethylamine; triphenylphosphine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ol035673b

Reference yield:

: 3878-55-5
methyl hydrogen succinate

: 628314-77-2
benzyl 2-[2-(methoxycarbonyl)ethyl]-5-{(1S)-1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-phenylethyl}-1,3-oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -20 °C

1.2: 78 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / 20 °C

2.1: 83 percent / PPh₃; I₂; Et₃N / CH₂Cl₂ / 2 h / 20 °C

With 4-methyl-morpholine; iodine; triethylamine; triphenylphosphine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol035673b

Reference yield:

: 103321-57-9
2S-flouren-9-ylmethoxycarbonylamino-3-phenylpropionyl chloride

: 628314-77-2
benzyl 2-[2-(methoxycarbonyl)ethyl]-5-{(1S)-1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2-phenylethyl}-1,3-oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuOK / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / 0.5 h / -78 °C

2.1: HCl / H₂O; tetrahydrofuran / 1 h / 20 °C

3.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -20 °C

3.2: 78 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / 20 °C

4.1: 83 percent / PPh₃; I₂; Et₃N / CH₂Cl₂ / 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium tert-butylate; iodine; triethylamine; triphenylphosphine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol035673b