Monomethyl succinate

Base Information

• Chemical Name: Monomethyl succinate
• CAS No.: 3878-55-5
• Molecular Formula: C5H8O4
• Molecular Weight: 132.116
• Hs Code.: 29171900
• European Community (EC) Number: 223-408-2
• NSC Number: 511
• UNII: YA2V724S0A
• DSSTox Substance ID: DTXSID7044425
• Nikkaji Number: J21.755G
• Wikidata: Q21045268
• Mol file: 3878-55-5.mol

Synonyms:3H-methylsuccinate;DL-methylsuccinate;methyl succinate;monomethyl succinate;monomethyl succinate sodium salt;succinic acid monomethyl ester

Chemical Property of Monomethyl succinate

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.00394mmHg at 25°C
• Melting Point: 54-57 °C(lit.)
• Refractive Index: 1.4240 (estimate)
• Boiling Point: 259.233 °C at 760 mmHg
• PKA: 4.42±0.17(Predicted)
• Flash Point: 104.549 °C
• PSA: 63.60000
• Density: 1.21 g/cm³
• LogP: 0.02420
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 132.04225873
• Heavy Atom Count: 9
• Complexity: 118

Purity/Quality:

99% ^*data from raw suppliers

Monomethyl Succinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Organic Acids
• Canonical SMILES: COC(=O)CCC(=O)O
• Uses: Mono-methyl Succinate is one of the substances used in the study of lactobacillus plantarum culture supernatants with potential pro-heating and anti-pathogenic properties in skin chronic wounds

Technology Process of Monomethyl succinate

There total 37 articles about Monomethyl succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

succinic acid anhydride (108-30-5) + methanol (67-56-1) → methyl hydrogen succinate (3878-55-5)

Guidance literature:

at 20 ℃;

DOI:10.1002/adsc.200600355

Reference yield: 100.0%

succinic acid anhydride (108-30-5) + sodium methylate (124-41-4) → methyl hydrogen succinate (3878-55-5)

Guidance literature:

In methanol; for 1.5h; Reflux; Inert atmosphere;

DOI:10.1021/jm400539d

Reference yield: 99.0%

succinic acid anhydride (108-30-5) → methyl hydrogen succinate (3878-55-5)

Guidance literature:

In methanol; for 2h; Reflux;

DOI:10.1021/acs.joc.0c00583

upstream raw materials:

succinic acid anhydride

methanol

bis-(3-methoxycarbonyl-propionyl)-peroxide

acetic acid

Downstream raw materials:

octane-1,8-dioic acid

hexanedioic acid dimethyl ester

7-methoxy-7-oxoheptanoic acid

N-phenylmaleimide

Refernces

• 1、 Wheatley, Bronwen M. M.,Keay, Brian A.. "Use of deuterium labeling studies to determine the stereochemical outcome of palladium migrations during an asymmetric intermolecular Heck reaction". . p. 7253 - 7259. Retrieved 2007.
• 2、 Dermeche, Leila,Idrissou, Yasmina,Mazari, Tassadit,Moudjahed, Mohammed,Rabia, Cherifa. "Oxidation of cyclohexanone and/or cyclohexanol catalyzed by Dawson-type polyoxometalates using hydrogen peroxide". . . Retrieved 2022/03/07.
• 3、 Agramunt, Jordi,Ginesi, Rebecca,Grandas, Anna,Pedroso, Enrique. "Inverse Electron-Demand Diels-Alder Bioconjugation Reactions Using 7-Oxanorbornenes as Dienophiles". . p. 6593 - 6604. Retrieved 2020/07/14.