(S)-1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid (4-{[1-amino-1-methoxy-meth-(Z)-ylidene]-sulfamoyl}-phenyl)-amide

Base Information

Chemical Name:(S)-1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid (4-{[1-amino-1-methoxy-meth-(Z)-ylidene]-sulfamoyl}-phenyl)-amide
CAS No.:276245-68-2
Molecular Formula:C₂₁H₂₅N₅O₇S₂
Molecular Weight:523.591
Hs Code.:

Synonyms:(S)-1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid (4-{[1-amino-1-methoxy-meth-(Z)-ylidene]-sulfamoyl}-phenyl)-amide

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Chemical Property of (S)-1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid (4-{[1-amino-1-methoxy-meth-(Z)-ylidene]-sulfamoyl}-phenyl)-amide

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Technology Process of (S)-1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid (4-{[1-amino-1-methoxy-meth-(Z)-ylidene]-sulfamoyl}-phenyl)-amide

There total 5 articles about (S)-1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid (4-{[1-amino-1-methoxy-meth-(Z)-ylidene]-sulfamoyl}-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1026820-47-2
C₂₀H₂₁N₅O₆S₂

: 276245-68-2
(S)-1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid (4-{[1-amino-1-methoxy-meth-(Z)-ylidene]-sulfamoyl}-phenyl)-amide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 4 ℃; for 96h;
DOI:10.1021/jm9903693

Reference yield:

: 116-47-2
sulfanilylcyanamide

: 276245-68-2
(S)-1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid (4-{[1-amino-1-methoxy-meth-(Z)-ylidene]-sulfamoyl}-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: EDCI*HCl; Et₃N / acetonitrile / 16 h / 4 °C

2: HCl(g) / dioxane / 96 h / 4 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; acetonitrile; 1: Condensation / 2: Addition;
DOI:10.1021/jm9903693

Reference yield:

: 4083-64-1
Tosyl isocyanate

: 276245-68-2
(S)-1-(Toluene-4-sulfonylaminocarbonyl)-pyrrolidine-2-carboxylic acid (4-{[1-amino-1-methoxy-meth-(Z)-ylidene]-sulfamoyl}-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: acetone / 4 h / 4 °C

2: EDCI*HCl; Et₃N / acetonitrile / 16 h / 4 °C

3: HCl(g) / dioxane / 96 h / 4 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; acetone; acetonitrile; 1: Condensation / 2: Condensation / 3: Addition;
DOI:10.1021/jm9903693