N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide hydrochloride

Base Information

Chemical Name:N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide hydrochloride
CAS No.:1338349-35-1
Molecular Formula:C₂₈H₃₉FN₂O*ClH
Molecular Weight:475.09
Hs Code.:

Synonyms:N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide hydrochloride

Chemical Property:

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Technology Process of N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide hydrochloride

There total 7 articles about N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338349-61-3
N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide

: 1338349-35-1
N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate;
DOI:10.1016/j.bmc.2011.07.030

Reference yield:

: 1184085-37-7
C₁₂H₁₄FN

: 1338349-35-1
N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium hydroxide; hydrogen / ethanol / 20 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Cooling with ice

3: hydrogenchloride / ethyl acetate / 18 h / 20 °C / Cooling with ice

4: sodium hydrogencarbonate / dichloromethane; water / 0.25 h / 20 °C / Saturated solution

5: potassium carbonate / acetonitrile / 15 h / 60 °C

6: hydrogenchloride / ethyl acetate

With hydrogenchloride; ammonium hydroxide; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.07.030

Reference yield:

: 1184231-96-6
C₁₂H₁₈FN

: 1338349-35-1
N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Cooling with ice

2: hydrogenchloride / ethyl acetate / 18 h / 20 °C / Cooling with ice

3: sodium hydrogencarbonate / dichloromethane; water / 0.25 h / 20 °C / Saturated solution

4: potassium carbonate / acetonitrile / 15 h / 60 °C

5: hydrogenchloride / ethyl acetate

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.07.030