N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide

Base Information

Chemical Name:N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide
CAS No.:1338349-61-3
Molecular Formula:C₂₈H₃₉FN₂O
Molecular Weight:438.629
Hs Code.:

Synonyms:N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide

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Chemical Property of N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide

Chemical Property:

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Technology Process of N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide

There total 5 articles about N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1184231-96-6
C₁₂H₁₈FN

: 1338349-61-3
N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Cooling with ice

2: hydrogenchloride / ethyl acetate / 18 h / 20 °C / Cooling with ice

3: sodium hydrogencarbonate / dichloromethane; water / 0.25 h / 20 °C / Saturated solution

4: potassium carbonate / acetonitrile / 15 h / 60 °C

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.07.030

Reference yield:

: 1184085-37-7
C₁₂H₁₄FN

: 1338349-61-3
N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide; hydrogen / ethanol / 20 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Cooling with ice

3: hydrogenchloride / ethyl acetate / 18 h / 20 °C / Cooling with ice

4: sodium hydrogencarbonate / dichloromethane; water / 0.25 h / 20 °C / Saturated solution

5: potassium carbonate / acetonitrile / 15 h / 60 °C

With hydrogenchloride; ammonium hydroxide; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.07.030

Reference yield:

: 1338349-59-9
N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide oxalate

: 1338349-61-3
N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(4-phenylbutyl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane; water / 0.25 h / 20 °C / Saturated solution

2: potassium carbonate / acetonitrile / 15 h / 60 °C

With sodium hydrogencarbonate; potassium carbonate; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2011.07.030