N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide oxalate

Base Information

Chemical Name:N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide oxalate
CAS No.:1338349-59-9
Molecular Formula:C₂H₂O₄*C₁₈H₂₇FN₂O
Molecular Weight:396.459
Hs Code.:

Synonyms:N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide oxalate

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Chemical Property of N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide oxalate

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Technology Process of N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide oxalate

There total 4 articles about N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1338349-27-1
tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate

: 144-62-7,97993-78-7
oxalic acid

: 1338349-59-9
N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide oxalate

Guidance literature:: tert-butyl 4-{[2-ethyl-2-(4-fluorophenyl)butyl]carbamoyl}piperidine-1-carboxylate; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 18h; Cooling with ice;

oxalic acid;
DOI:10.1016/j.bmc.2011.07.030

Reference yield:

: 1184085-37-7
C₁₂H₁₄FN

: 1338349-59-9
N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide oxalate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide; hydrogen / ethanol / 20 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Cooling with ice

3: hydrogenchloride / ethyl acetate / 18 h / 20 °C / Cooling with ice

With hydrogenchloride; ammonium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.030

Reference yield:

: 1184231-96-6
C₁₂H₁₈FN

: 1338349-59-9
N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide oxalate

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Cooling with ice

2: hydrogenchloride / ethyl acetate / 18 h / 20 °C / Cooling with ice

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.030