N,alpha-Dimethyl-N-(phenylmethyl)benzenemethanamine

Base Information

• Chemical Name: N,alpha-Dimethyl-N-(phenylmethyl)benzenemethanamine
• CAS No.: 10419-51-9
• Molecular Formula: C₁₆H₁₉N
• Molecular Weight: 225.334
• DSSTox Substance ID: DTXSID101244216
• Nikkaji Number: J595.429K
• Mol file: 10419-51-9.mol

Synonyms:SCHEMBL8027272;DTXSID101244216;10419-51-9

Chemical Property of N,alpha-Dimethyl-N-(phenylmethyl)benzenemethanamine

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 225.151749610
• Heavy Atom Count: 17
• Complexity: 202

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)N(C)CC2=CC=CC=C2

Technology Process of N,alpha-Dimethyl-N-(phenylmethyl)benzenemethanamine

There total 10 articles about N,alpha-Dimethyl-N-(phenylmethyl)benzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + O-benzoyl N-methyl N-benzylhydroxylamine → N-benzyl-N-α-phenylethyl-p-toluidine (10419-51-9)

Guidance literature:

With 1,2-bis(bis(3,5-bis(trifluoromethyl)phenyl)phosphanyl)benzene; copper diacetate; lithium tert-butoxide; HSiPh₃; In 1,2-dichloro-ethane; at 20 ℃; for 4h; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201304365

Reference yield: 83.0%

N-methyl-N-benzyl-(1-phenylvinyl)amine (86774-89-2) → N-benzyl-N-α-phenylethyl-p-toluidine (10419-51-9)

Guidance literature:

With n-butyllithium; (S,S,S)-(ETBTHI)TiO₂Binap; phenylsilane; hydrogen; In tetrahydrofuran; at 65 ℃; for 24h; under 4137.2 Torr;

DOI:10.1021/ja00092a066

Reference yield: 77.0%

methanol (67-56-1) + N-benzylidene-α-methylbenzylamine (17480-71-6,56941-77-6,62696-51-9,69350-13-6,89103-76-4,98393-39-6,3129-98-4) → N-benzyl-N-α-phenylethyl-p-toluidine (10419-51-9)

Guidance literature:

With C₂₅H₂₇ClIrN₄⁽¹⁺⁾*Cl^(1-); caesium carbonate; at 125 ℃; for 12h; Schlenk technique;

DOI:10.1016/j.jcat.2021.08.037

upstream raw materials:

N-methyl-N-(1-phenylethyl)amine

benzyl chloride

N-methyl-N-benzyl-(1-phenylvinyl)amine

methylmagnesium bromide