ethyl 5-(4-methylphenyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate

Base Information

• Chemical Name: ethyl 5-(4-methylphenyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate
• CAS No.: 131292-06-3
• Molecular Formula: C₃₂H₂₇O₃P
• Molecular Weight: 490.538
• Mol file: 131292-06-3.mol

Synonyms:ethyl 5-(4-methylphenyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate

Chemical Property of ethyl 5-(4-methylphenyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(4-methylphenyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate

There total 3 articles about ethyl 5-(4-methylphenyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

p-Tolyl-propynoyl chloride (62849-00-7) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → ethyl 5-(4-methylphenyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate (131292-06-3)

Guidance literature:

With triethylamine; In toluene; for 3h; Ambient temperature;

DOI:10.1039/P19940002461

Reference yield:

3-(4-methylphenyl)prop-2-ynoic acid (2227-58-9) → ethyl 5-(4-methylphenyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate (131292-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) aq. NaOH, 2.) SOCl₂ / 2) ether, reflux, 6 h

2: 91 percent / Et₃N / toluene / 3 h / Ambient temperature

With sodium hydroxide; thionyl chloride; triethylamine; In toluene;

DOI:10.1039/P19940002461

Reference yield:

ethyl 3-(4-methylphenyl)prop-2-ynoate (52188-06-4) → ethyl 5-(4-methylphenyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate (131292-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH, benzyltriethylammonium chloride / H₂O; diethyl ether / 120 h

2: 1.) aq. NaOH, 2.) SOCl₂ / 2) ether, reflux, 6 h

3: 91 percent / Et₃N / toluene / 3 h / Ambient temperature

With sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; triethylamine; In diethyl ether; water; toluene;

DOI:10.1039/P19940002461

upstream raw materials:

p-Tolyl-propynoyl chloride

ethyl (triphenylphosphoranylidene)acetate

3-(4-methylphenyl)prop-2-ynoic acid

ethyl 3-(4-methylphenyl)prop-2-ynoate

Downstream raw materials:

ethyl 7-(4-methylphenyl)-3-oxo-2-triphenylphosphoranylidenehepta-4,6-diynoate

5-p-Tolyl-penta-2,4-diynoyl chloride

5-p-Tolyl-pentadiin-(2.4)-saeure

ethyl 5-(4-methylphenyl)penta-2,4-diynoate