(S)-4-Benzyl-3-{2-[(R)-1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-propionyl}-oxazolidin-2-one

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Chemical Name:(S)-4-Benzyl-3-{2-[(R)-1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-propionyl}-oxazolidin-2-one
CAS No.:648414-71-5
Molecular Formula:C₃₀H₃₀N₂O₅
Molecular Weight:498.579
Hs Code.:

Synonyms:(S)-4-Benzyl-3-{2-[(R)-1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-propionyl}-oxazolidin-2-one

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Chemical Property of (S)-4-Benzyl-3-{2-[(R)-1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-propionyl}-oxazolidin-2-one

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Technology Process of (S)-4-Benzyl-3-{2-[(R)-1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-propionyl}-oxazolidin-2-one

There total 6 articles about (S)-4-Benzyl-3-{2-[(R)-1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-propionyl}-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 648411-32-9
(S)-4-Benzyl-3-{2-[(R)-1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-acetyl}-oxazolidin-2-one

: 74-88-4
methyl iodide

: 648414-71-5
(S)-4-Benzyl-3-{2-[(R)-1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-propionyl}-oxazolidin-2-one

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran;
DOI:10.1016/S0960-894X(03)00313-5

Reference yield:

: 179533-67-6
(R)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)hex-5-enoate

: 648414-71-5
(S)-4-Benzyl-3-{2-[(R)-1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-propionyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / O₃; PPh₃ / CH₂Cl₂

2: NaBH(OAc)3 / 1,2-dichloro-ethane

3: toluene / Heating

4: 100 percent / CF₃CO₂H / CH₂Cl₂

5: 83 percent / PivCl; Et₃N; BuLi / tetrahydrofuran

6: 42 percent / KHMDS / tetrahydrofuran

With n-butyllithium; pivaloyl chloride; potassium hexamethylsilazane; sodium tris(acetoxy)borohydride; ozone; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1016/S0960-894X(03)00313-5

Reference yield:

: 300856-46-6
[(R)-1-(4-Benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-acetic acid

: 648414-71-5
(S)-4-Benzyl-3-{2-[(R)-1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-propionyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / PivCl; Et₃N; BuLi / tetrahydrofuran

2: 42 percent / KHMDS / tetrahydrofuran

With n-butyllithium; pivaloyl chloride; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran;
DOI:10.1016/S0960-894X(03)00313-5