ethyl 2-[2-{N-(1-[2,4-dimethoxyphenyl]ethyl)methacrylamido}-4-methylpentanamido]acetate

Base Information

• Chemical Name: ethyl 2-[2-{N-(1-[2,4-dimethoxyphenyl]ethyl)methacrylamido}-4-methylpentanamido]acetate
• CAS No.: 1598420-56-4
• Molecular Formula: C₂₄H₃₆N₂O₆
• Molecular Weight: 448.56
• Mol file: 1598420-56-4.mol

Synonyms:ethyl 2-[2-{N-(1-[2,4-dimethoxyphenyl]ethyl)methacrylamido}-4-methylpentanamido]acetate

Chemical Property of ethyl 2-[2-{N-(1-[2,4-dimethoxyphenyl]ethyl)methacrylamido}-4-methylpentanamido]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[2-{N-(1-[2,4-dimethoxyphenyl]ethyl)methacrylamido}-4-methylpentanamido]acetate

There total 4 articles about ethyl 2-[2-{N-(1-[2,4-dimethoxyphenyl]ethyl)methacrylamido}-4-methylpentanamido]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

poly(methacrylic acid) (79-41-4,25087-26-7,50867-57-7) + Ethyl isocyanoacetate (2999-46-4) + (S)-α-(2,4-dimethoxyphenyl)ethylamine (1212264-50-0) + isovaleraldehyde (590-86-3) → ethyl 2-[2-{N-(1-[2,4-dimethoxyphenyl]ethyl)methacrylamido}-4-methylpentanamido]acetate (1598420-63-3) + ethyl 2-[2-{N-(1-[2,4-dimethoxyphenyl]ethyl)methacrylamido}-4-methylpentanamido]acetate (1598420-56-4)

Guidance literature:

(S)-α-(2,4-dimethoxyphenyl)ethylamine; isovaleraldehyde; In ethanol; at 20 ℃; for 0.5h;

poly(methacrylic acid); Ethyl isocyanoacetate; In ethanol; at 0 - 20 ℃; for 24h; Overall yield = 44 %;

DOI:10.1016/j.tetasy.2014.01.016

Reference yield:

2',4'-dimethoxyacetophenone (829-20-9) → ethyl 2-[2-{N-(1-[2,4-dimethoxyphenyl]ethyl)methacrylamido}-4-methylpentanamido]acetate (1598420-56-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonium carbonate / water / 2 h / 135 °C / Reflux

1.2: Reflux

2.1: sodium hydroxide / water / 4 h / Reflux

3.1: Novozym 435 / toluene / 48 h / 25 °C / Enzymatic reaction

4.1: ethanol / 0.5 h / 20 °C

4.2: 24 h / 0 - 20 °C

With ammonium carbonate; sodium hydroxide; In ethanol; water; toluene; 4.1: |Ugi Condensation / 4.2: |Ugi Condensation;

DOI:10.1016/j.tetasy.2014.01.016

Reference yield:

α-(2,4-dimethoxyphenyl)ethyl amine (188894-33-9) → ethyl 2-[2-{N-(1-[2,4-dimethoxyphenyl]ethyl)methacrylamido}-4-methylpentanamido]acetate (1598420-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Novozym 435 / toluene / 48 h / 25 °C / Enzymatic reaction

2.1: ethanol / 0.5 h / 20 °C

2.2: 24 h / 0 - 20 °C

With Novozym 435; In ethanol; toluene; 2.1: |Ugi Condensation / 2.2: |Ugi Condensation;

DOI:10.1016/j.tetasy.2014.01.016

upstream raw materials:

2',4'-dimethoxyacetophenone

α-(2,4-dimethoxyphenyl)ethyl amine

poly(methacrylic acid)

Ethyl isocyanoacetate