3-(2-cyclohexyl-1H-imidazol-4-yl)-propionic acid methyl ester

Base Information

• Chemical Name: 3-(2-cyclohexyl-1H-imidazol-4-yl)-propionic acid methyl ester
• CAS No.: 775350-40-8
• Molecular Formula: C₁₃H₂₀N₂O₂
• Molecular Weight: 236.314
• Mol file: 775350-40-8.mol

Synonyms:3-(2-cyclohexyl-1H-imidazol-4-yl)-propionic acid methyl ester

Chemical Property of 3-(2-cyclohexyl-1H-imidazol-4-yl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(2-cyclohexyl-1H-imidazol-4-yl)-propionic acid methyl ester

There total 3 articles about 3-(2-cyclohexyl-1H-imidazol-4-yl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

methyl 3-(4-imidazolyl)propionate (31434-93-2) + Cyclohexanecarboxylic acid (98-89-5) → 3-(2-cyclohexyl-1H-imidazol-4-yl)-propionic acid methyl ester (775350-40-8)

Guidance literature:

With ammonium peroxydisulfate; silver nitrate; In sulfuric acid; at 70 - 80 ℃;

DOI:10.1016/j.ejmech.2004.05.005

Reference yield:

trans-4-imidazoleacrylic acid methyl ester hydrochloride (54260-89-8) → 3-(2-cyclohexyl-1H-imidazol-4-yl)-propionic acid methyl ester (775350-40-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / H₂; Et₃N / Pd/C / methanol / 24 h / 20 °C / atmospheric pressure

2: 10 percent / AgNO₃; (NH₄)2S₂O₈ / aq. H₂SO₄ / 70 - 80 °C

With ammonium peroxydisulfate; hydrogen; silver nitrate; triethylamine; palladium on activated charcoal; In methanol; sulfuric acid;

DOI:10.1016/j.ejmech.2004.05.005

Reference yield:

urocanic Acid (3465-72-3) → 3-(2-cyclohexyl-1H-imidazol-4-yl)-propionic acid methyl ester (775350-40-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / HCl / 20 °C

2: 93 percent / H₂; Et₃N / Pd/C / methanol / 24 h / 20 °C / atmospheric pressure

3: 10 percent / AgNO₃; (NH₄)2S₂O₈ / aq. H₂SO₄ / 70 - 80 °C

With hydrogenchloride; ammonium peroxydisulfate; hydrogen; silver nitrate; triethylamine; palladium on activated charcoal; In methanol; sulfuric acid;

DOI:10.1016/j.ejmech.2004.05.005

upstream raw materials:

methyl 3-(4-imidazolyl)propionate

Cyclohexanecarboxylic acid

trans-4-imidazoleacrylic acid methyl ester hydrochloride

urocanic Acid