(E)-4-(2-(dimethylamino)vinyl)-6-(4-fluorophenyl)-2-((4-isopropylphenyl)amino) nicotinonitrile

Base Information

Chemical Name:(E)-4-(2-(dimethylamino)vinyl)-6-(4-fluorophenyl)-2-((4-isopropylphenyl)amino) nicotinonitrile
CAS No.:1428522-50-2
Molecular Formula:C₂₅H₂₅FN₄
Molecular Weight:400.499
Hs Code.:

Synonyms:(E)-4-(2-(dimethylamino)vinyl)-6-(4-fluorophenyl)-2-((4-isopropylphenyl)amino) nicotinonitrile

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Chemical Property of (E)-4-(2-(dimethylamino)vinyl)-6-(4-fluorophenyl)-2-((4-isopropylphenyl)amino) nicotinonitrile

Chemical Property:

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Technology Process of (E)-4-(2-(dimethylamino)vinyl)-6-(4-fluorophenyl)-2-((4-isopropylphenyl)amino) nicotinonitrile

There total 4 articles about (E)-4-(2-(dimethylamino)vinyl)-6-(4-fluorophenyl)-2-((4-isopropylphenyl)amino) nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428522-37-5
6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1428522-50-2
(E)-4-(2-(dimethylamino)vinyl)-6-(4-fluorophenyl)-2-((4-isopropylphenyl)amino) nicotinonitrile

Guidance literature:: In N,N-dimethyl-formamide; at 130 ℃; for 3h;
DOI:10.1016/j.tetlet.2013.02.016

Reference yield:

: 2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile

: 1428522-50-2
(E)-4-(2-(dimethylamino)vinyl)-6-(4-fluorophenyl)-2-((4-isopropylphenyl)amino) nicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 10 h / 90 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3.5 h / 100 °C / Inert atmosphere

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

4: N,N-dimethyl-formamide / 3 h / 130 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; johnphos; sodium t-butanolate; trichlorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 2: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.02.016

Reference yield:

: 875-35-4
2,6-dichloro-4-methylnicotinonitrile

: 1428522-50-2
(E)-4-(2-(dimethylamino)vinyl)-6-(4-fluorophenyl)-2-((4-isopropylphenyl)amino) nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3.5 h / 100 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 3 h / 130 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; johnphos; sodium t-butanolate; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 1: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.02.016