6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile

Base Information

Chemical Name:6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile
CAS No.:1428522-37-5
Molecular Formula:C₂₂H₂₀FN₃
Molecular Weight:345.419
Hs Code.:

Synonyms:6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile

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Chemical Property of 6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile

Chemical Property:

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Technology Process of 6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile

There total 3 articles about 6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 99-88-7
4-Isopropylaniline

: 943117-82-6
2-chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile

: 1428522-37-5
6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate; In toluene; at 100 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.02.016

Reference yield:

: 2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile

: 1428522-37-5
6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 10 h / 90 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3.5 h / 100 °C / Inert atmosphere

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; johnphos; sodium t-butanolate; trichlorophosphate; In 1,4-dioxane; water; toluene; 2: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.02.016

Reference yield:

: 875-35-4
2,6-dichloro-4-methylnicotinonitrile

: 1428522-37-5
6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3.5 h / 100 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; johnphos; sodium t-butanolate; In 1,4-dioxane; water; toluene; 1: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.02.016