5-(4-fluorophenyl)-10-isopropyl-7H-benzo[h]pyrido[4,3,2-de][1,6]naphthyridine

Base Information

Chemical Name:5-(4-fluorophenyl)-10-isopropyl-7H-benzo[h]pyrido[4,3,2-de][1,6]naphthyridine
CAS No.:1428522-63-7
Molecular Formula:C₂₃H₁₈FN₃
Molecular Weight:355.414
Hs Code.:

Synonyms:5-(4-fluorophenyl)-10-isopropyl-7H-benzo[h]pyrido[4,3,2-de][1,6]naphthyridine

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Chemical Property of 5-(4-fluorophenyl)-10-isopropyl-7H-benzo[h]pyrido[4,3,2-de][1,6]naphthyridine

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Technology Process of 5-(4-fluorophenyl)-10-isopropyl-7H-benzo[h]pyrido[4,3,2-de][1,6]naphthyridine

There total 5 articles about 5-(4-fluorophenyl)-10-isopropyl-7H-benzo[h]pyrido[4,3,2-de][1,6]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1428522-50-2
(E)-4-(2-(dimethylamino)vinyl)-6-(4-fluorophenyl)-2-((4-isopropylphenyl)amino) nicotinonitrile

: 1428522-63-7
5-(4-fluorophenyl)-10-isopropyl-7H-benzo[h]pyrido[4,3,2-de][1,6]naphthyridine

Guidance literature:: With sulfuric acid; at 70 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.02.016

Reference yield:

: 2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile

: 1428522-63-7
5-(4-fluorophenyl)-10-isopropyl-7H-benzo[h]pyrido[4,3,2-de][1,6]naphthyridine

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 10 h / 90 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3.5 h / 100 °C / Inert atmosphere

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

4: N,N-dimethyl-formamide / 3 h / 130 °C

5: sulfuric acid / 70 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; johnphos; sodium t-butanolate; trichlorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 2: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.02.016

Reference yield:

: 1428522-37-5
6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile

: 1428522-63-7
5-(4-fluorophenyl)-10-isopropyl-7H-benzo[h]pyrido[4,3,2-de][1,6]naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 3 h / 130 °C

2: sulfuric acid / 70 °C / Inert atmosphere

With sulfuric acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2013.02.016